Guidelines for the management of atopic dermatitis in children: A
systematic review of the literature and quality appraisal with AGREE II
Abstract
Background: Numerous guidelines have been published for atopic
dermatitis management in children in recent years. To date, the quality
of the newest guidelines has not been appraised. Objective: To
identify and evaluate guidelines for the management of atopic dermatitis
in children. Design: A review of the guidelines for the
management of atopic dermatitis in children and quality appraisal with
AGREE II was conducted. Methods: We reviewed literature
retrieved from PubMed, Web of Science, Ovid, ScienceDirect, Embase,
China National Knowledge Infrastructure, WanFang Data, and guidelines
websites. Search period from 1 January 2016 to 31 December 2021. The
following keywords were used for searching: ‘atopic dermatitis’, ‘atopic
eczema’, ‘eczema’, ‘guideline’ and ‘consensus’. The quality of the
guidelines was assessed by two assessors using the Appraisal of
Guidelines for Research & Evaluation II (AGREE II) instrument
independently, and domain scores were considered of sufficient quality
when > 60%. Guidelines recommendations were reviewed.
Results: Nineteen guidelines were included in the study. Three
guidelines were graded A level that recommended for use in practice.
Eleven guidelines were graded B level that recommended for use in
revision. The remaining five guidelines were rated C level not as
recommended. The average score of six domains of AGREE II was 64.76%,
48.53%, 42.35%, 73.83%, 32.23% and 70.17%, respectively. The
consistency test showed that ICC ranged from 0.497 (95%CI: 0.105,
0.705) to 0.970 (95%CI: 0.93, 0.987) in the results of two assessors’
tests of the guidelines. Conclusions: Most guidelines were
recommended for use with revision in the study. No major changes in
primary management of atopic dermatitis in children compared to previous
evidence. New biologic agents and complementary alternative medicine
were increasingly available, but evidence for the treatment of atopic
dermatitis in children was still limited.