loading page

Predictive factors of egg allergy clinical outcomes in infants and young children
  • Xiaoyan Mo,
  • Jiajia Lv,
  • Jie Shao
Xiaoyan Mo
Hefei City First People's Hospital
Author Profile
Jiajia Lv
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Library
Author Profile
Jie Shao
Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital Library
Author Profile

Abstract

Aim: The aim of the present study was to explore the tolerance march in children and establish probable factors that affect the prognosis of an egg allergy (EA). Methods: Two hundred children 6 months to 2.5 years old with atopic dermatitis (AD) were recruited into our study from 2018 to 2019. EA was diagnosed based on medical history, the skin prick test (SPT), and the oral food challenge test (OFC) ,EA was diagnosed in 78,among those, 7 were allergic only to egg yolk (OnlyEYA), 20 to egg white (OnlyEWA), and 51 to whole egg (WEA). Logistic regression analysis was used to detect the disease course and related risk factors of outcomes. The receiver operating characteristic curve was used to establish a predicting model. Results:The Scoring Atopic Dermatitis score in the WEA group was more severe and persistent than that in the other groups. Forty-three cases of EA developed clinical tolerance (average age, 32.3 ± 8.7 months). The tolerance rate of EYA was 75.9% and EWA was 56.3%. The SPT wheal diameter at initial diagnosis (SPT diag) was the risk factor for persistent EA. The SPT wheal diameter after 6 months (△SPT 6mo) in the tolerant group decreased markedly compared to that in the persistent EA group. Tolerance was higher when △EW-SPT 6mo ≥ 39.5% or △EY-SPT 6mo ≥ 27%. Conclusion: The initial SPT diag and SPT 6mo values were significantly correlated with and can predict outcomes of EA. Key words: Egg allergy, atopic dermatitis, outcome, related factors.