Dear Editor, I am writing to submit a letter titled “Usage of a Novel Inhaler Device for the Management of Asthma in Children with Special Needs” for your consideration. This letter highlights the importance of the inhaler device technique in children with asthma when they have comorbid conditions such as attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD). These comorbidities often make it challenging for physicians to plan a treatment regimen, as it impacts the patient’s adherence to medication. We evaluated the effectiveness of a breath-actuated inhaler (BAI) in managing poorly controlled asthma in three pediatric patients with special needs. All patients showed significant improvement in their asthma symptoms, were well-controlled after one month of using the BAI and they found that device was easy to use. This letter contributes to the growing body of evidence supporting the effectiveness of BAI in the management of asthma, particularly in children with special needs. We hope this work to be submitted under the letter to editor section and it will be of interest to your readership and contribute to improving asthma management in children with comorbidities. Thank you for your consideration.