Global warming rise has been observed as a result of ozone layer destruction, which makes it possible for UVB radiation to pass through atmosphere and kill people. It is believed that daily exposure to UVB radiation has biological effects on both humans and other living things. Concerning effect of UVB radiations, we examine the instinctive mechanism by which a specific amount of radiation induces oxidative stress and hyperthyroidism, which is further controlled by the antioxidant activity of Naringin (NG), due to the detrimental effects of UVB radiation on the biological system. For these examinations twenty-four adult male albino mice were divided into four equal groups; control group, UVB exposed group (2 hrs/day), UVB+NG treated group (80 mg/kg b.w), and NG-treated group. Doses were given orally, daily for 15 consecutive days. Specimens of the thyroid gland were processed for hormonal, biochemical, histological, immunohistochemical and immunofluorescence examinations. A morphometric study and statistical analysis of the findings were performed for different groups. Compared to the control group, the specimens of the UVB exposed mice showed alteration in mean height of the thyroid follicular epithelial cells and caspase-3, NOS-2 and THRβ-1 expression. In contrast, naringin prevent the changes caused due to repeated UVB radiations.