Abstract Introduction: Human metapneumovirus (HMPV) was recently recognized as an important cause of seasonal respiratory tract infections mainly in children and immunocompromised adults. The use of Charlson Comorbity index (CCI) to predict outcome in hospitalized patients has been validated in several settings. Objective: Describe the clinical characteristics of adult patients with HMPV infection, evaluate the value to the CCI in predicting outcome. Methods: Single center retrospective chart review study of hospitalized patients with HMPV infection in 2017. Results: 22 adult patients with a mean age of 65 years were reviewed. The mean CCI was 4.6±2.6. The overall mortality was 22%. Abnormal chest radiograph (CXR) was reported in 15 patients. CCI was not different between survivors and non survivors. Non survivors were more likely to have abnormal CXR and higher fever at the time of diagnosis, required mechanical ventilation or were treated for other concomitant infections. Conclusion: The average of CCI was 4.5 which was not significantly different between survivors and non survivors. Mortality rate was elevated at 22% and is likely associated with admission to the ICU and presence of another concomitant infection.