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Evaluation of Microalgal Extracts as a Potential Surgical Suture Coating Material
  • Merve Tokgöz,
  • Çağla Yarkent,
  • Suphi Oncel
Merve Tokgöz
Ege University
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Çağla Yarkent
Ege University
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Suphi Oncel
Ege University

Corresponding Author:[email protected]

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Abstract

Background: Sutures act as excellent surfaces that allow bacteria to penetrate wounds. In this way, they cause microbial colonization, biofilm formation, and thus surgical sites infection. Such side effects have a great impact on the human life quality. Therefore, the concerns about this issue are increasing rapidly. At this point, microalgae have been drawn attention with their high-biologically active compounds. In this study, A. platensis, H. pluvialis, C. minutissima, B. braunii and N. muscorum extracts were investigated for their usability potential as surgical suture covering material. Methods: In order to evaluate their biocompatibility, the antibacterial activities and cytotoxic effects of the sutures [PGLA and PDO] coated with these extracts were determined. Major results: The results showed that A. platensis and N. muscorum extracts have acceptable cytotoxic levels on L929 cell line according to ISO 10993-5. Moreover, A. platensis extract was found to be the most promising suture coating material for the human applications. Conclusions: The surgical sutures have been successfully coated with extracts derived from microalgae species. As a result, it has been proven that antibacterial sutures could be obtained, and the biological properties of surgical sutures could be improved by using microalgal antibacterial extracts. In summarize, it appears as microalgal extracts can used in biological materials with potential application in the pharmaceutical industries due to its ingredients.