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\begin{document}

\title{Making new ways of understanding very small building-blocks of life
using picture-taking-boxes with a very large make-bigger-power}



\author[1]{Martin Jones }%
\affil[1]{The Francis Crick Institute}%


\vspace{-1em}



  
  \date{May 21, 2024}


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\begin{figure}[h!]
\begin{center}
\includegraphics[width=0.28\columnwidth]{figures/FIB-SEM/FIB-SEM}
\caption{{One of our picture-taking-boxes with a very large make-bigger-power
{\label{977837}}%
}}
\end{center}
\end{figure}

We use picture-taking-boxes with a very large make-bigger-power to take
pictures of the very small building blocks that make up humans and other
animals. We can also see the tiny things that do important stuff inside
these building blocks. These tiny things are interesting because we need
to understand them to see why people get sick and how to make them
better. If there isn't a box that does what we need, we build a new one
that does! Sometimes we even make boxes that go inside other boxes so we
can take different kinds of pictures all at once to tell us different
things.

The boxes make lots of pictures so we need good ways to understand them
quickly with computers. To do this we need to carefully give the
computer lots of orders and numbers to control what they do so they do
good work. At the moment, even with the best computers this is too hard
and takes too long, so we need to think of better ways to train the
computer to do good work more quickly. Often we have to ask a person to
do the work as they still do it best, but slowly.

We have started to ask tens of hundreds of people around the world to
help us as they can do good work together more quickly than one person.
We can also get them to help us train the computers to do better work in
up-coming times. The people that help us are aged from school children
all the way up to older people who don't have to go to work any more,
and everything in between.

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\begin{figure}[h!]
\begin{center}
\includegraphics[width=0.70\columnwidth]{figures/Screen-Shot-2017-11-17-at-20-57-06/Screen-Shot-2017-11-17-at-20-57-06}
\caption{{Place where tens of hundreds of people from all around the world have
helped us do good work and understand the building blocks in bodies and
why people get sick
{\label{384555}}%
}}
\end{center}
\end{figure}

\par\null

{[}For more info, see our citizen science project ``Etch a
cell''~\url{https://www.zooniverse.org/projects/h-spiers/etch-a-cell}~and
our hardware development
work~\url{https://wellcomeopenresearch.org/articles/1-26/v1}{]}

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