Conclusion
In conclusion, in this cohort study, high maternal pre-pregnancy BMI
appeared to be the most influential upstream risk factor for gestational
hyperglycaemia/hypertriglyceridemia in mothers and increased
birthweight/insulin secretion in neonates. Our findings based on robust
novel statistical methods highlights the impact of maternal
pre-pregnancy BMI on maternal and neonatal metabolic outcomes. We also
found that maternal hyperglycaemia was positively associated with
elevated neonatal insulin secretion, suggesting this may be a key reason
for foetal fat deposition. By contrast, maternal lipid levels do not
appear to have meaningful independent associations with neonatal
birthweight or CBI.