Population
Between March 2017 and April 2019 a prospective cohort was created of consecutive singleton pregnancies with early-onset severe PE who were admitted to the Departments of Maternal-Fetal Medicine at BCNatal (Barcelona, Spain), comprising two referral university hospitals (Hospital Clínic and Hospital Sant Joan de Déu). Additional inclusion criteria were the absence of maternal complications at admission (as detailed below) and the absence of fetal indication for imminent delivery. The study protocol was approved by the Ethics Committee (HCB/2017/0077) and participants provided their written informed consent.