Abstract
Background: Castleman disease is an infrequent disease that
affects the lymph nodes and related tissues. The condition may manifest
with lymphadenopathy, characterized by the enlargement of the lymph
nodes, alongside additional symptoms such as high fever, nocturnal
sweating, exhaustion, and loss of body mass. The diagnosis of Castleman
disease typically entails a multifaceted approach that includes a
physical examination, imaging modalities, and a biopsy of the lymph
nodes that are affected. The selection of treatment modalities is
contingent upon the classification and extent of the disease. Systemic
lupus erythematosus (SLE) has been identified as a potential risk factor
for the development of lymphoma, a condition that may manifest with
lymphadenopathy resembling Castleman disease. Hence, it is crucial for
individuals diagnosed with SLE and exhibiting lymphadenopathy to undergo
a comprehensive assessment to exclude the possibility of any other
associated disease. Although lymphadenopathy is a common symptom shared
by both Castleman illness and SLE, these diseases have distinct
etiologies and are treated in different ways. Seeking advice from a
healthcare practitioner is crucial in order to obtain an accurate
diagnosis and effective treatment.
Case presentation: A 39-year-old female patient with a history
of SLE since 18 years ago and lupus nephritis since six years ago which
treated with Mycophenolic Acid 2 grams daily, Hydroxychloroquine 400 mg
daily, and low doses of Prednisolone. Also, Mycophenolic Acid has
discontinued for him five months ago due to the reduction of proteinuria
and the control of the disease