3.1.4 Host tyrosine kinase receptor
Receptor tyrosine kinases (RTKs) are a group of growth factor receptors
that are autophosphorylated after ligand binding (Lemmon and
Schlessinger, 2010). Dong et al introduced an RTK inhibitor named (A9)
as a robust inhibitor of transmissible gastroenteritis virus (TGEV)
infection belong to Alphacoronavirus genera as a surrogate model for CoV
in cell-based assays (Dong et al., 2020). The specific RTK inhibitors
(RTKIs), known as AG879 and tyrphostin A9 (A9), are also reported as
strong antiviral activity against the influenza A virus (Kumar et al.,
2011). It was shown that blocking the receptor kinase activity by
approved inhibitors broadly impair infection by all major HCV genotypes
and viral escape variants in cell culture and in a human liver chimeric
mouse model (Jilg and Chung, 2012). The tyrosine kinase inhibitor such
as genistein can block the replication of HIV-1, herpes simplex virus
type 1 (HSV-1) and Arenavirus (Vela et al., 2008). These findings
suggest a potentially promising host-centered approach like RTKs to
treat the 2019-nCoV.