Statistical analysis
We calculated median and interquartile range (IQR), or absolute numbers and percentages to describe the variables measured. To compare variables between groups, we used Student’s T-test or Wilcoxon rank sum test depending on the distribution of the variables, with Bonferroni correction for multiple comparisons. We compared clinical variables, LU scores and RS at the different moments analysed between the two groups.
Differences were considered statistically significant if p<0.05. We used STATA v.14.2 (StataCorp. 2015. Stata Statistical Software : Release 14. College Station, TX, USA: StataCorp LP.).