Statistical analysis
We calculated median and interquartile range (IQR), or absolute numbers
and percentages to describe the variables measured. To compare variables
between groups, we used Student’s T-test or Wilcoxon rank sum test
depending on the distribution of the variables, with Bonferroni
correction for multiple comparisons. We compared clinical variables, LU
scores and RS at the different moments analysed between the two groups.
Differences were considered statistically significant if
p<0.05. We used STATA v.14.2 (StataCorp. 2015. Stata
Statistical Software : Release 14. College Station, TX, USA: StataCorp
LP.).