Susceptibility of I38-substituted viruses to baloxavir acid (BXA) was
determined by plaque reduction assay, and fold change (FC) was
calculated as relative EC50 of each tested virus to that
of the cognate wild-type virus. Bold, clinically confirmed amino acid
substitutions.
aData from reference.10
bData obtained from the current study is shown, while
FCs of A(H1N1) viruses with I38S and I38L were previously reported as
52- and 9-fold, respectively.25
cThe recombinant PA/I38R viruses were not
reverse-genetically rescued.