ACKNOWLEDGEMENTS
Robert Webster (St. Jude Children’s Research Hospital, Memphis) kindly
provided materials for reverse genetics. We appreciate acknowledge
Takeki Uehara, Kenji Tsuchiya, Keiko Kawaguchi, Toru Ishibashi and
Naohisa Kitade (Shionogi & Co. Ltd.) for analyzing and providing
clinical data. We acknowledge Satoshi Kojima and Masahiro Kinoshita for
assistance in manuscript preparation. We thank Makoto Iwasaki, Michie
Watanabe, Saya Nishimori-Yamaki, and all members of Shionogi
TechnoAdvance Research, Co., Ltd. for excellent technical assistance.
The work on this project was supported with research funds provided by
Shionogi & Co., Ltd. Osaka, Japan and F. Hoffmann-La Roche Ltd, Basel,
Switzerland.