Amino acid substitution in PA subunit Amino acid substitution in PA subunit FC of BXA FC of BXA
rgA/WSN/33 (H1N1) rgA/Victoria/3/75 (H3N2)
Treatment-emergent substitutions
I38T
27.24a
56.59a
I38F 10.61a 20.13a
I38M 13.15a 13.77a
I38N 23.66 10.32
I38S 12.43b 5.85
I38R Not rescuedc Not rescuedc
Polymorphic substitutions I38V 2.18 1.83
I38L 6.33b 2.17