Statistical Analysis
The collected data were analyzed using software statistical computer package SPSS version 24.0 (IBM Corp., Armonk, NY, USA). Continuous normally distributed variables were expressed as mean ± SD. Continuous non-normally distributed variables were expressed as median ± IQR. Student t-test was used to determine the difference between the two groups of normally distributed variables. Mann-Whitney U test and Wilcoxon signed-rank were used to determine the difference between the two groups of non-normally distributed variables. Categorical variables are presented as number and percentage and were analyzed using the Chi-Square test or Fisher exact test. After Kaplan-Meier analysis, survival curves were compared using Log Rank test. Receiver Operating Characteristics (ROC) was plotted as sensitivity on Y axis and 1-specificity on X axis. The significance level was set at p< 0.05.