Figures
Figure 1: Network of relationships for Mycobacterium tuberculosisBeijing A isolates from Panama based on whole genome sequencing data. Each dot represents a single-nucleotide polymorphism. When two isolates are in the same box, they show no single-nucleotide polymorphism between them. mv, median vector corresponding to not-sampled nodes; REF: Most recent common ancestor. Isolate with single-locus-variant (SLV) as per the MIRU-VNTR analysis (the remaining isolates with SLVs did not offer enough coverage in the whole genome sequencing analysis for single-nucleotide polymorphism calls). *isolate collected in 2015.
Figure 2. Phylogenetic reconstruction of Panamanian Beijing isolates. Maximum-likelihood phylogeny inferred from 5,809 variable single-nucleotide positions of the 26 isolates rooted with the H37Rv (NC_000962.3) reference strain. The most recent common ancestor “genome” was constructed and compared against modern and ancestral Beijing strains datasets.
Figure 3. Maximum clade credibility tree (BEAST) to infer the estimated circulation time of the Beijing strain in Panama of Panama clade groups (26 isolates) with strains isolated in Vietnam (Ho Chi Minh City) and the British Columbia (most likely foreign-born from South-East Asia). Posterior probabilities of nodes are in grayscale (ranging from 0.0 – 1.0). Node ages with 95% HPD ranges are indicated as blue bars.