4. Prognostic factors
Reported prognostic factors associated with poor outcome include
elevated LDH (20), acute kidney injury
(20), proteinuria (>30
mg/dL)(23), and raised plasma sC5b-9 at
diagnosis (23). Patients with proteinuria
and elevated sC5b-9 at diagnosis had 84% mortality while all patients
without proteinuria or elevated sC5b-9 survived. Pulmonary hypertension
is another poor prognostic factor with 80% mortality
(30). Elevated right ventricular pressure
at day +7 post-transplant was significantly associated with subsequent
development of TA-TMA (25,
31).