4. Prognostic factors
Reported prognostic factors associated with poor outcome include elevated LDH (20), acute kidney injury (20), proteinuria (>30 mg/dL)(23), and raised plasma sC5b-9 at diagnosis (23). Patients with proteinuria and elevated sC5b-9 at diagnosis had 84% mortality while all patients without proteinuria or elevated sC5b-9 survived. Pulmonary hypertension is another poor prognostic factor with 80% mortality (30). Elevated right ventricular pressure at day +7 post-transplant was significantly associated with subsequent development of TA-TMA (25, 31).