Effect of mixed-mode and surface-modified column chromatography
on virus filtration performance
Hironobu Shirataki,1 Yoshiro
Yokoyama,2 Ryota Oguri2
1Scientific Affairs Group, Bioprocess Division, Asahi
Kasei Medical Co., Ltd., 1-1-2 Yurakucho, Chiyoda-ku, Tokyo 100-0006
2Technology Development Department, Bioprocess
Division, Asahi Kasei Medical Co., Ltd., 5-4960 Nakagawara-machi,
Nobeoka-shi, Miyazaki-ken 882-0031
Corresponding author: Hironobu Shirataki, Scientific Affairs Group,
Bioprocess Division, Asahi Kasei Medical Co., Ltd., 1-1-2 Yurakucho,
Chiyoda-ku, Tokyo 100-0006
email: shirataki.hb@om.asahi-kasei.co.jp
Keywords: clogging model, column chromatography, virus
filtration
Abbreviations: List here in alphabetical order. HCP, host cell
protein; mAb, monoclonal antibody; SEC, size exclusion chromatography;
Vmax, maximum filtration volume