Viral clearance in end-to-end continuous process for mAb
purification: Total flow-through integrated polishing on two columns
connected to virus filtration
Hironobu Shirataki1, Yoshihiro
Matsumoto2, Fuminori Konoike3,
Shuichi Yamamoto4
1Scientific
Affairs Group, Bioprocess Division, Asahi Kasei Medical Co., Ltd.,
1-1-2, Yurakucho, Chiyoda-ku, Tokyo 100-0006, Japan
2Yokohama R&D Center, JNC Corporation, 5-1, Ookawa,
Kanazawa-ku, Yokohama-shi, Kanagawa, 236-8605, Japan
3Bio-Pharma Research Laboratories, Kaneka Corporation,
1-8, Miyamae-cho, Takasago-cho, Takasago-shi, Hyogo, 676-8688, Japan
4 Yamaguchi University Biomedical Engineering Center
(YUBEC), Yamaguchi University, 2-16-1 Tokiwadai, Ube, Yamaguchi
755-8611, Japan
Corresponding author: Hironobu Shirataki, Scientific Affairs Group,
Bioprocess division, Asahi Kasei Medical Co., Ltd., 1-1-2, Yurakucho,
Chiyoda-ku, Tokyo 100-0006, Japan.
email:
shirataki.hb@om.asahi-kasei.co.jp
Co-author email addresses
Yoshihiro Matsumoto: ymatsumoto@jnc-corp.co.jp
Fuminori Konoike: Fuminori.Konoike@kaneka.co.jp
Shuichi Yamamoto: shuichi@yamaguchi-u.ac.jp
Short running title: Viral clearance in continuous mAb process
This research was supported by grant number JP18ae0101056, JP18ae0101057
and JP18ae0101058 from the Japan Agency for Medical Research and
Development (AMED)
Conflict of interest disclosure