Parameters Non-seizure Control (n=8) MTLE-HS (n=9)
Spontaneous EPSCs Spontaneous EPSCs Spontaneous EPSCs
Frequency (Hz) 0.68 ± 0.01 0.98 ± 0.04***
Amplitude (pA) 12.05 ± 0.16 15.07 ± 0.38**
Rise time (ms) 1.9 ± 0.7 2.0 ± 0.6
Decay time constant (τd, ms) 9.6 ± 1.4 9.4 ± 0.9
Spontaneous IPSCs Spontaneous IPSCs Spontaneous IPSCs
Frequency (Hz) 1.76 ± 0.04 1.73 ± 0.05
Amplitude (pA) 22.86 ± 0.41 21.24 ± 0.48
Rise time (ms) 2.9 ± 0.7 2.8 ± 0.4
Decay time constant (τd, ms) 32.4 ± 3.8 33.1 ± 1.5
Spontaneous EPSCs after incubation with 200µM kynurenine (KYN) Spontaneous EPSCs after incubation with 200µM kynurenine (KYN) Spontaneous EPSCs after incubation with 200µM kynurenine (KYN)
Non-seizure Control (n=6) Control 200 µM KYN (n=6)
Frequency (Hz) 0.67 ± 0.02 0.33 ± 0.01***
Amplitude (pA) 12.53 ± 0.23 7.86 ± 0.20***
Rise time (ms) 2.0 ± 0.3 2.1 ± 0.5
Decay time constant (τd, ms) 9.3 ± 1.2 9.4 ± 1.8
MTLE-HS (n=16) MTLE-HS 200 µM KYN (n=16)
Frequency (Hz) 1.00 ± 0.07 0.97 ± 0.13
Amplitude (pA) 15.39 ± 0.20 14.99 ± 0.22
Rise time (ms) 2.2 ± 0.3 2.3 ± 0.9
Decay time constant (τd, ms) 9.0 ± 1.1 9.1 ± 1.8
Spontaneous EPSCs after perfusion with 10µM kynurenic acid (KYNA) Spontaneous EPSCs after perfusion with 10µM kynurenic acid (KYNA) Spontaneous EPSCs after perfusion with 10µM kynurenic acid (KYNA)
Non-seizure Control (n=6) Control 10 µM KYNA (n=6)
Frequency (Hz) 0.65 ± 0.05 0.54 ± 0.02***
Amplitude (pA) 12.51 ± 0.26 10.23 ± 0.24***
Rise time (ms) 1.9 ± 0.7 1.9 ± 0.4
Decay time constant (τd, ms) 9.7 ± 1.4 9.5 ± 2.0
MTLE-HS (n=10) MTLE-HS 10 µM KYNA (n=10)
Frequency (Hz) 1.06 ± 0.09 0.73 ± 0.02***
Amplitude (pA) 16.29 ± 0.30 12.06 ± 0.29***
Rise time (ms) 2.0 ± 0.6 2.3 ± 0.7
Decay time constant (τd, ms) 9.6 ± 0.8 9.4 ± 0.9