The concentration of metabolites in the hippocampal samples was
correlated with seizure duration of patients with MTLE-HS
To investigate whether there was any correlation between the
concentration of TKP metabolites (KYNA and its de novo synthesis,
QUIN and its de novo synthesis, PLP) and total duration of
seizure (duration between age of seizure onset and age of surgery as all
patients achieve seizure freedom of Engel class I following surgery), we
examined the concentration of each metabolite and it’s de novosynthesis of each patient and correlated it with duration of seizure
using non-parametric Spearman’s correlation test. We observed that the
concentration of KYNA (Figure 7a) and its de novo synthesis
(Figure 7b) were inversely correlated with the duration of seizure. The
concentration of PLP was also inversely correlated with the duration of
seizure (Figure 7e). Although the concentration of QUIN was correlated
with the duration of seizure (Figure 7c) but we could not observe any
correlation between de novo synthesis of QUIN and the duration of
seizure (Figure 7d).