List of abbreviations:
MTLE-HS: Mesial temporal lobe epilepsy with hippocampal sclerosis; nAChR: nicotinic acetyl choline receptors; KP: tryptophan-kynurenine pathway; KYNA: kynurenic acid; KYN: L-kynurenine; TRP: Tryptophan; IDO: indoleamine 2,3‑ dioxygenase; KAT II: kynurenine aminotransferase; PLP: pyridoxal phosphate; PNPO: Pyridoxamine 5’-Phosphate Oxidase; QUIN: quinolinic acid; KMO: Kynurnine-3-monooxygenase; EPSCs: excitatory postsynaptic currents; IPSCs: inhibitory postsynaptic currents.