The concentration of metabolites in the hippocampal samples was correlated with seizure duration of patients with MTLE-HS
To investigate whether there was any correlation between the concentration of TKP metabolites (KYNA and its de novo synthesis, QUIN and its de novo synthesis, PLP) and total duration of seizure (duration between age of seizure onset and age of surgery as all patients achieve seizure freedom of Engel class I following surgery), we examined the concentration of each metabolite and it’s de novosynthesis of each patient and correlated it with duration of seizure using non-parametric Spearman’s correlation test. We observed that the concentration of KYNA (Figure 7a) and its de novo synthesis (Figure 7b) were inversely correlated with the duration of seizure. The concentration of PLP was also inversely correlated with the duration of seizure (Figure 7e). Although the concentration of QUIN was correlated with the duration of seizure (Figure 7c) but we could not observe any correlation between de novo synthesis of QUIN and the duration of seizure (Figure 7d).