Key Results
We observed significantly reduced KYNA and elevated QUIN levels in the
hippocampal samples, while KYN level remains unaltered. Spontaneous
glutamatergic activity in the hippocampal samples was higher compared to
that in non-seizure controls. Treatment with kynurenine inhibited the
glutamatergic activity in non-seizure control samples but not in case of
the hippocampal samples. However, exogenously applied KYNA inhibited
glutamatergic activity in both non-seizure control and hippocampal
samples. We also observed reduced levels of enzyme kynurenine
aminotransferase II and its co-factor pyridoxal phosphate in the
hippocampal samples.