Spontaneous EPSCs |
Spontaneous EPSCs |
Spontaneous EPSCs |
Frequency (Hz) |
0.68 ± 0.01 |
0.98 ± 0.04*** |
Amplitude (pA) |
12.05 ± 0.16 |
15.07 ± 0.38** |
Rise time (ms) |
1.9 ± 0.7 |
2.0 ± 0.6 |
Decay time constant (τd, ms) |
9.6 ± 1.4 |
9.4 ±
0.9 |
Spontaneous IPSCs |
Spontaneous IPSCs |
Spontaneous IPSCs |
Frequency (Hz) |
1.76 ± 0.04 |
1.73 ± 0.05 |
Amplitude (pA) |
22.86 ± 0.41 |
21.24 ± 0.48 |
Rise time (ms) |
2.9 ± 0.7 |
2.8 ± 0.4 |
Decay time constant (τd, ms) |
32.4 ± 3.8 |
33.1 ±
1.5 |
Spontaneous EPSCs after incubation with 200µM kynurenine (KYN) |
Spontaneous EPSCs after incubation with 200µM kynurenine
(KYN) |
Spontaneous EPSCs after incubation with 200µM
kynurenine (KYN) |
|
Non-seizure Control (n=6) |
Control 200 µM KYN
(n=6) |
Frequency (Hz) |
0.67 ± 0.02 |
0.33 ± 0.01*** |
Amplitude (pA) |
12.53 ± 0.23 |
7.86 ± 0.20*** |
Rise time (ms) |
2.0 ± 0.3 |
2.1 ± 0.5 |
Decay time constant (τd, ms) |
9.3 ± 1.2 |
9.4 ±
1.8 |
|
MTLE-HS (n=16) |
MTLE-HS 200 µM KYN
(n=16) |
Frequency (Hz) |
1.00 ± 0.07 |
0.97 ± 0.13 |
Amplitude (pA) |
15.39 ± 0.20 |
14.99
± 0.22 |
Rise time (ms) |
2.2 ± 0.3 |
2.3 ± 0.9 |
Decay time constant (τd, ms) |
9.0 ± 1.1 |
9.1 ±
1.8 |
Spontaneous EPSCs after perfusion with 10µM kynurenic acid
(KYNA) |
Spontaneous EPSCs after perfusion with 10µM kynurenic
acid (KYNA) |
Spontaneous EPSCs after perfusion with 10µM
kynurenic acid (KYNA) |
|
Non-seizure Control (n=6) |
Control 10 µM KYNA
(n=6) |
Frequency (Hz) |
0.65 ± 0.05 |
0.54 ± 0.02*** |
Amplitude (pA) |
12.51 ± 0.26 |
10.23 ± 0.24*** |
Rise time (ms) |
1.9 ± 0.7 |
1.9 ± 0.4 |
Decay time constant (τd, ms) |
9.7 ± 1.4 |
9.5 ±
2.0 |
|
MTLE-HS (n=10) |
MTLE-HS 10 µM KYNA
(n=10) |
Frequency (Hz) |
1.06 ± 0.09 |
0.73 ± 0.02*** |
Amplitude (pA) |
16.29 ± 0.30 |
12.06 ± 0.29*** |
Rise time (ms) |
2.0 ± 0.6 |
2.3 ± 0.7 |
Decay time constant (τd, ms) |
9.6 ± 0.8 |
9.4 ±
0.9 |