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\begin{document}

\title{Cystic fibrosis-related mortality trends in Mexico between 1999 -- 2020}



\author[1]{Adriana Bustamante}%
\author[1]{Lucia Fernandez}%
\author[1]{Lissette Rivas}%
\author[1]{Roberto Mercado Longoria}%
\affil[1]{Hospital Universitario Dr Jose Eleuterio Gonzalez}%


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  \date{June 18, 2024}


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\begin{abstract}
\textbf{Background.} Cystic fibrosis (CF) is an autosomal recessive
disorder associated with an increased susceptibility to respiratory
infections that cause progressive decline in lung function and lead to
lung damage and chronic respiratory failure. To analyze the CF-related
mortality trends in the Mexican population during a 22-year period. ~We
conducted a mortality trend analysis using death certificates data.
Trends in CF-specific and in age-specific mortality rates were evaluated
using Joinpoint regression analysis. Among subjects [?]40 years, 1184
CF-related deaths were identified. In 1999--2009 median age at death was
7 years compared to 10 years in 2010--2020. Overall mortality rate
increased from 0.03 per 100,000 in 1999 to 0.06 per 100,000 in 2020. A
decline in mortality rate for patients [?]28 days and an increase in
mortality rate in older age groups was observed. \textbf{Conclusion.}
The increasing trend in overall mortality, associated with a downward
trend in neonatal mortality and an increase in median age at death is
conceivably due to enhanced diagnosis, as well as major advances in
treatment modalities, leading to higher survival rates. \textbf{Key
words:} age at death, cystic fibrosis, epidemiology, low- and
middle-income countries, mortality, survival rate.%
\end{abstract}%



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