Variables N (samples) Absolute concentration# Absolute concentration# Absolute concentration# Daily dose Daily dose Daily dose C:D ratio# C:D ratio# C:D ratio# Risk of undetectable serum conc. Risk of undetectable serum conc. Risk of undetectable serum conc.
Average (CI)*
Beta (SE)
p
Average (CI)*
Beta (SE)
p
Average (CI)*
Beta (SE)
p
OR (CI) Coefficient (SE)
P
Intercept 6.0 (0.17) <0.001 39 (4.1) <0.001 2.36 (0.18) <0.001 0.071 -2.7 (0.35) <0.001
CYP2D6 UM/NM CYP2D6 IM CYP2D6 PM 133 (276) 99 (204) 27 (66) 6.0 (5.8, 6.3) 6.5 (6.2, 6.7) 7.9 (7.5, 8.4) 0 (0) 0.45 (0.16) 1.9 (0.24) - 0.006 <0.001 58 (53, 63) 49 (44, 55) 45 (35, 56) 0 (0) -8.8 (3.8) -13 (5.9) - 0.022 0.029 2.11 (1.9, 2.3) 2.77 (2.5, 3.0) 4.37 (3.9, 4.8) 0 (0) 0.66 (0.17) 2.26 (0.26) - <0.001 <0.001 0 (0) 0.50 (0.26, 0.96) 0.34 (0.10, 1.1) 0 (0) -0.70 (0.33) -1.1 (0.60) - 0.037 0.068
CYP2C19 non-carriers CYP2C19*2 carriers 173 (390) 86 (156) 6.6 (6.4, 6.8) 7.0 (6.7, 7.3) 0 (0) 0.37 (0.16) - 0.022 51 (47, 56) 50 (44, 57) 0 (0) -1.1 (3.8) - 0.78 2.87 (2.7, 3.1) 3.30 (3.0, 3.6) 0 (0) 0.44 (0.17) - 0.011 0 (0) 1.6 (0.88, 3.0) 0 (0) 0.48 (0.31) - 0.12
Age (per year)
-0.005 (0.005)
0.31
0.83 (0.13)
<0.001
-0.020 (0.006)
<0.001
1.0 (1.0, 1.1) 0.031 (0.01)
0.002
Pseudo R2 (marginal/ conditional) 0.167 / 0.401 0.167 / 0.401 0.167 / 0.401 0.163 / 0.618 0.163 / 0.618 0.163 / 0.618 0.248 / 0.526 0.248 / 0.526 0.248 / 0.526
#The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error #The values are presented as ln-transformed values to ensure normal distribution. The average values were calculated with linear mixed model with age as covariate (the value of age is shown as *23.4 years). CYP, cytochrome P450; UM, ultra-rapid metabolizers; NM, normal metabolizers; IM, intermediate metabolizers; PM, poor metabolizers; CI, 95% confidence intervals; SE, standard error