Participants and data sources
Eligible consecutive patients were identified from a regional head and
neck cancer database (SOMERSET), who had a histological diagnosis of
locally advanced (AJCC 8 T3 or T4) laryngeal squamous cell carcinoma
(ICD-10 C32.9) and underwent definitive either radiotherapy or
chemoradiotherapy with curative intent between 2008 and 2018 at a
tertiary head and neck centre. Patients received radiotherapy at a dose
of 65-70Gy over 30-35 fractions with or without concurrent cisplatin
chemotherapy delivered at either 3- or 4-week intervals at a dose of
100mg/m2. All patients were discussed in the regional multidisciplinary
team meeting before commencement of treatment. Demographic, clinical and
radiological characteristics (cartilage involvement, pre-epiglottic
extension) were extracted from the electronic medical records.