Introduction
Congenital ichthyosis is a heterogeneous group of Mendelian disorders
characterized by hyperkeratosis and extensive scaling of the epidermal
skin layer due to mutations in genes that play a critical role in
epidermal differentiation. Several genetic mutations have been
associated with the disease, demonstrating an autosomal recessive,
autosomal dominant, and X-linked recessive pattern of inheritance. (1,2)
Multiple sclerosis (MS) is an autoimmune inflammatory disease primarily
involving the central nervous system, causing variable neurologic
manifestations which can ultimately lead to neurologic deterioration.
(3,4)
In this study, we describe a case of congenital ichthyosis that
presented with signs and symptoms of MS to our clinic. Although the
co-occurrence of the disease can be a coincidence, the event is uncommon
and has been rarely reported.