3.3.1 | All-cause mortality
Mortality data were reported in 11 studies 14-23,26,
in which one study 26 had a mortality rate of 0, so it
was not included in the meta-analysis. There was no significant
difference in the mortality rate between the MISA group and the control
group (Risk ratio (RR) : 0.75, 95% confidence interval (CI) : 0.56 to
1.00, I2 = 8%, p = .05, 10 studies14-23 (n = 1478)).
As the subjects in two studies 14,19 were preterm
infants at < 29 weeks and for the control group, instead of
choosing INSURE techniques for surfactant delivery, the authors selected
a more traditional approach, that is, continuous mechanical ventilation
after surfactant instillation with endotracheal intubation, sensitivity
analysis yielded different results (RR : 0.69, 95% CI : 0.51 to 0.95, p
= .02, I2 = 17%, 8 studies15-18,20-23 (n = 1047))
(Figure 2A).