3.3.4 | Need for mechanical ventilation during hospitalization
In this meta-analysis, the random effect model (REM) was applied, as significant heterogeneity was observed in the fixed-effect model (FEM) (I2 = 72%). Meta-analysis estimated that the MISA group had a lesser need for mechanical ventilation during hospitalization (RR : 0.64, 95% CI : 0.49 to 0.82, p = .0005, 8 studies14-17,19,21-23 (n = 1350)). The heterogeneity did not change significantly after removing each trial one by one. The exclusion of two studies 14,19 yielded similar results and failed to significantly reduce the heterogeneity (RR : 0.66, 95% CI : 0.48 to 0.91, I2 = 51%, p = .01, 6 studies15-17,21-23 (n = 919)) (Figure 2D).