Omicron variant
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B.1.1.529
The S1-RBD/S2 mutation/deletion
(the alterations of SARS-CoV-2 S RNA sequences) lead to escape immune
surveillance.
The 3.0 Å cryo-EM structure of the omicron spike protein shows extensive
mutations in RBD regions.
Key mechanisms: binding of the RBD of the viral spike protein with the
ACE2 receptor in the host-cells, improved host-cell entry and the
replication of the virus.
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More infectious sites of SARS-CoV-2 and more than existed deadly Delta
variants
Spread globally,
increased hospitalization,
exhibited more severity for the young generation,
invaded defense mechanism of natural immunity;
Not responsive to the available vaccines, and significant resistance to
current antibody therapies.
Extraordinary potency in immune escape compared to the other
variants
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On Nov 26th 2021, WHO designated the new SARS-CoV-2 strain – named
Omicron, from letter ”όμικρον” in the Greek alphabet – as a variant
of concern (B.1.1529 variant)
RBD: the receptor-binding domain;
ACE2: the angiotensin-converting enzyme 2.
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