CONCLUSIONS
Since unhealthy E(e)SEEDi lifestyle links to the new origins and novel mechanisms of fCVD, the author setup a fresh theory, that is, the “brain-heart-gut” axis. The novel mechanisms of fCVD are mediated by the role of “environment-sleep-emotion-exercise-diet” and the gut microbiota in early life, which is like a “Golden Hoop Curse”. On the one hand, the “brain-heart-gut” axis provides a theoretical basis not only for the cardiovascular health benefits of “keeping the pubic region” advocated by traditional Chinese medicine, but also for the control and prevention of both eCVD and fCVD; On the other hand, “keeping the pubic region” is the best example on the fresh theory of “brain-heart-gut” axis. As a new theory, the “brain-heart-gut” axis will help us to earlier and better prevent and control both eCVD and fCVD with healthy E(e)SEEDi lifestyle.