The “brain-heart-gut” axis and novel mechanisms of future cardiovascular disease (fCVD).
The new origins and novel mechanisms of fCVD link to the “brain-heart-gut” axis disrupted by early unhealthy E(e)SEEDi lifestyle, which is like a “Golden Hoop Curse”. In the “brain-heart-gut” axis, the brain is the decision system, the heart is the power system, the gut is the execution system. The three closely cooperate and interact with each other to form the new mechanisms of fCVD. Here, E: environment (external); e: environment (internal); S: sleep; Em: emotion; Ex: exercise; D: diet. E(e)SEEDi: “environment-sleep-emotion-exercise-diet” intervention. Green : positive biofeedback by healthy E(e)SEEDi lifestyle; Grey : negative disruption by unhealthy E(e)SEEDi lifestyle.