This article introduces briefly current status in type 2 diabetes (T2D) and an updated classical standardized comprehensive program which combines optimal medical treatment (OMT) with lifestyle modification, that is, intervention of RT-ABCDEFG (iRT-ABCDEFG) for control and prevention of T2D, and discusses its advantages and prospects. Here, G means goals, F follow-up, E examination, D disease & risk factors control, C changing unhealthy lifestyle & Chinese medicine or control the source of infection & cutting genetic or spreading pathways, B biohazard control, and A antagonistic treatment, such as anti-diabetic agents, the glucagon-like peptide-1 receptor (GLPR) agonists, the sodium-glucose cotransporter 2 (SGLT2) inhibitors, and the ultralong-acting, once-daily basal insulin. As an effective comprehensive program and strategy for Interventions of diabetes, this program can be used as a Reverse, Right, and Routine Treatment (iRT). Several pivotal goals which include less major adverse cardiocerebrovascular events (MACCE) and diabetic complications, less medical costs, longer life expectancy, lower morbidity and mortality, and higher quality of life, will be realized by consistently practicing this program due to early diagnosis, OMT, and lifestyle modification for overall prevention. Herein, this iRT-ABCDEFG program is worthy of recommending for clinical professional management and health care of T2D due to better cost-effectiveness.