2.2.2 Remedial dosing strategies
Six remedial strategies were developed considering their clinical
feasibility and our previous studies20. Remedial
strategies are the action patient will take when they remember their
missed dose. Remedial strategies refer to actions that patients will
take when they remember their missed dose. As edoxaban tablets are
divisible, we included a half dose in our remedial strategy to provide a
more precise approach. We tested both the current recommendations from
the EHRA guide and our developed remedial strategies. Our remedial
strategy is similar to our previous study in rivaroxaban, which are
shown in Figure 2 and detailed below 20:
Strategy A: skip the full delayed dose and take the next dose
as schedule.
Strategy B: take the full delayed dose immediately and take the
next dose as schedule.
Strategy C: take a half delayed dose immediately and take the
next dose as schedule
Strategy D: take a full delayed dose immediately followed by a
half dose at the next scheduled time, and then resume the regular dosing
regimen.
Strategy E: take one and a half delayed doses immediately, skip
the next scheduled dose, and then resume the regular dosing regimen.
Strategy F: take a double of delayed dose, skip the next
scheduled dose, and then resume the regular dosing regimen.
EHRA guide: take the delayed dose if less than 12 h late;
otherwise, skip the delayed or missed dose and administer the next dose
at the scheduled time.