Central nervous system (CNS) infections constitute a significant etiology of seizures. However, the likelihood of such infections is contingent upon factors such as age, immunological status, and geographic region. Borrelia burgdorferi , a Spirochaete, is responsible for the infectious etiology of seizures in Lyme disease. The case under consideration pertains to a patient who exhibited seizures as the initial manifestation of neuroborreliosis. A male patient, aged 55, was admitted to the emergency department due to the sudden onset of tonic-clonic seizures. All standard laboratory examinations yielded unremarkable outcomes, except a favorable Wright and 2-mercaptoethanol test. The examination of cerebrospinal fluid revealed the presence of 380 white blood cells per milliliter. Additionally, the protein level was elevated, while the glucose level was within the normal range. The results of the serologic tests indicated the presence of both IgG and IgM antibodies to B. burgdorferi . Following the administration of ceftriaxone, a significant improvement was observed in the patient’s medical status, and he was subsequently discharged.

Keywords: Central Nervous System Infections; Borrelia Infections; Lyme Neuroborreliosis