* Correspondence to Ling Ding
Department of Pharmacy, Chongqing University Jiangjin Hospital, 725
Jiangzhou Avenue, Jiangjin District, Chongqing, 402260, China
Tel.+86 23 47225178
E-mail: dingling0244@yeah.net (Ling Ding)
Keywords: Beta-lactams,
Piperacillin, Cefoperazone, Cross reactions, Thrombocytopenia
Word count : 1864 words
Table count : 2
Figure count : 1
Abstract
Beta-lactam antibiotics are a relatively common cause of immune
thrombocytopenia. Cross-reactivity of them in patient with drug-induced
immune thrombocytopenia is rarely reported. Here, we describe the case
of a 79-year-old male patient
experienced
thrombocytopenia after receiving
piperacillin-tazobactam
for acute exacerbation of chronic obstructive pulmonary disease
(AECOPD). Fortunately, the patient was able to successfully challenge
with meropenem and cefotiam. However, after the
cefoperazone-sulbactam
was administered, the patient experienced thrombocytopenia again.
Therefore, there are cross-reactions of platelet-relative antibodies
between piperacillin-tazobactam and cefoperazone-sulbactam. Although the
exact responsible antibodies remain unknown and need further
investigation, attention should be
paid to the role of chemical structure similarities in determining the
risk of immune thrombocytopenia among beta-lactams in the clinical
setting.