Abstract
Purpose: The purpose of our study was to explore the
relationship between EAT thickness and left atrial phasic function in
patient with non-valvular atrial fibrillation (NVAF).
Methods: 100 NVAF patients were enrolled, including 50 patients
with paroxysmal AF and 50 patients with persistent AF. Another 50
patients without AF in sinus rhythm were selected as the control group.
EAT thickness in front of the right ventricular free wall was measured
using transthoracic echocardiography(TTE) at end-systole, while left
atrial phasic function parameters were measured by Real-time
three-dimensional
echocardiography(RT-3DE) and two-dimensional speckle tacking
imaging(2D-STI), including left atrial total emptying fraction(LATEF),
left atrial active emptying fraction(LAAEF), left atrial passive
emptying fraction(LAPEF), left atrial
reservoir strain(LASr), left atrial contraction strain(LASct) and left
atrial conduit strain(LAScd). Subsequently, we compared EAT thickness
and left atrial phasic function parameters in each group, and analyzed
the relationship between EAT thickness and left atrial phasic function
parameters.
Results : Compared
with control group, patients with paroxysmal AF and persistent AF groups
had sequentially greater EAT
thickness and left atrial diameter (LAD), but sequentially lower left
atrial phasic function parameters (LATEF, LAAEF, LAPEF, LASr, LASct,
LAScd) (all p<0. 001). By Pearson and Spearman Correlation
Coefficient, EAT thickness was significantly positively correlated with
LAD and negatively correlated with left atrial phasic function
parameters (all p<0. 001).
Conclusions: EAT thickness in front of the ventricular free
wall measured by TTE was significantly correlated with left atrial
phasic function in patients with NVAF, which could effectively reflect
the trend of left atrial function changes, thus providing some reference
for clinical practice and early intervention of left atrial remodeling.