Parameter SPL026 9 mga
(n=5) SPL026 12 mga (n=6) SPL026 17 mga,b (n=5) SPL026 21.5 mga (n=6)
Cmax, ng/mL
Mean (SD)
20.8 (12.9)
30.6 (18.1)
72.1 (47.1)
62.7 (25.8)
Range
5.0–34.9
12.7–62.3
16.2–126.0
29.0–107.0
CV (%)
0.62
0.59
0.65
0.41
Tmax, min
Median (range)
9.6 (7.0–11.0)
10.5 (6.0–11.2)
9.8 (9.7–11.3)
9.7 (9.7–11.0)
AUClast, ng.min/mL
Mean (SD)
349 (253)
451 (229)
842 (453)
835 (231)
Range
71–705
245–755
204–1298
477–1052
CV (%)
0.72
0.51
0.54
0.28
AUCinf, ng.min/mL
Mean (SD)
352 (252)
455 (229)
-
837 (231)
Range
75–707
249–763
-
478–1054
CV (%)
0.72
0.50
-
0.28
t1/2, min
Mean (SD)
12.1 (4.7)
9.5 (4.0)
-
12.1 (5.2)
Range
5.8–18.3
6.0–17.0
-
6.3–20.3
CV (%)
0.39
0.42
-
0.43
CL, L/min
Mean (SD)
46.0 (43.6)
32.4 (14.6)
-
27.9 (9.7)
Range
12.7–120.0
15.7–48.2
-
20.4–45.0
CV (%)
0.95
0.45
-
0.35
Vz, L
Mean (SD)
611 (308)
425 (214)
-
456 (157)
Range
241–996
172–683
-
218–653
CV (%)
0.50
0.50
-
0.34
Vss, L
Mean (SD)
551 (346)
375 (173)
-
400 (149)
Range
246–1094
157–587
-
215–673
CV (%)
0.63
0.46
-
0.37
MRTinf, min
Mean (SD)
14.6 (4.1)
12.4 (5.6)
-
15.0 (5.0)
Range
9.1–19.3
8.6–23.3
-
8.4–20.1
CV (%)
0.28
0.45
-
0.33