AUTHOR CONTRIBUTIONS
RT designed and performed the experiments, collected experimental data and wrote the paper draft; YCP helped designed the study, performed experiments and the paper writing; LYD assisted Dot blot assay and animal experiments; YHL, LLY took part and assisted in some experiments; YMF, TGD made constructive suggestions on the experimental design and data analysis; XL provided the laboratory where experiments being conducted,financial supports, designed the study, and finished final writing of the paper.