Abstract
The vagina links the organs where gynecologic tumors are located to the
outside world. A healthy acidic vaginal environment relies on
lactobacilli; a dysregulated vaginal flora is associated with the
occurrence, unsatisfactory treatment and poor prognosis of gynecologic
malignancies. Using microbial markers to screen the difficult-to-detect
characteristics of early tumors may play a key role in prolonging the
survival of cancer patients. The discovery of microbes within tumor has
led to the consideration of the immunological relevance of internal
microorganisms to tumors. This article aims to review the relevance of
microorganisms within the above two environments to gynecologic
malignancies.