Immune response
As a remote protein, Cas9 may actuate the safe reaction. In spite of the
fact that there are not numerous reports approximately the extreme safe
response caused by Cas9, the antibodies of Cas9 have been broadly
recognized in human bodies [140], which recommends the potential
hazard of aggravation amid CRISPR/Cas9-based quality treatment. At show,
analysts pay more consideration to the immunogenicity caused by
conveyance vectors, particularly the viral vectors, since the human body
may have been tainted by these infections some time recently and contain
the comparing antibodies as of now. Collectively, the safe response
possibly actuated by CRISPR/Cas9 gene-editing framework is one of the
major hazard components within the improvement of CRISPR-based quality
treatment in vivo.