Delivery system Cargo options benefits Flaws
Polymer nanoparticles
RNP plasmid DNA RNP complex Cas9 mRNA sgRNA Donor DNA High biocompatibility Low immunogenicity Reduce off-target effects Can be mass produced Low cost Toxicity Limited delivery efficiency
Golden nanoparticles
RNP plasmid DNA RNP complex Cas9 mRNA sgRNA Donor DNA High biocompatibility Low immunogenicity Reduce off-target effects Can be mass produced Low cost
Limited delivery efficiency
Lipid nanoparticles
RNP plasmid DNA RNP complex Cas9 mRNA sgRNA Donor DNA High biocompatibility Low immunogenicity Reduce off-target effects Can be mass produced Low cost
Degradation in vivo