Polymer nanoparticles
|
RNP plasmid DNA
RNP complex
Cas9 mRNA
sgRNA
Donor DNA
|
High biocompatibility
Low immunogenicity
Reduce off-target effects
Can be mass produced
Low cost
|
Toxicity
Limited delivery efficiency
|
Golden nanoparticles
|
RNP plasmid DNA
RNP complex
Cas9 mRNA
sgRNA
Donor DNA
|
High biocompatibility
Low immunogenicity
Reduce off-target effects
Can be mass produced
Low cost
|
Limited delivery efficiency
|
Lipid nanoparticles
|
RNP plasmid DNA
RNP complex
Cas9 mRNA
sgRNA
Donor DNA
|
High biocompatibility
Low immunogenicity
Reduce off-target effects
Can be mass produced
Low cost
|
Degradation in vivo
|