Results
The 176 patients included in the study received 2,320 infusions.
Fifty-eight patients (33.0%) experienced IRRs, and IRRs occurred in 80
(3.4%) of the 2,320 infusions. Owing to the hierarchical structure of
the data, the independence of the observed values was evaluated using
the intraclass correlation coefficient. Multivariate multilevel logistic
regression analysis showed that premedication with dexamethasone was
effective in lowering IRR risk with trastuzumab (mg; per unit; odds
ratio, OR=0.62; 95% confidence interval, 95% CI, 0.44‒0.86;p =0.005). Preoperative status (OR=34.7; 95% CI, 5.0–242.0;p <0.001) and high doses of trastuzumab (mg/kg; per
unit; OR=59.6; 95% CI, 19.7–180.0; p <0.001) were
independent risk factors for IRRs.