PCIS can be used to study anti-allergic drugs
Antihistamines were used to
demonstrate the suitability of PCIS as a model of FA to assess specific
mechanisms of action. Pre-treatment of the tissue with the
antihistamines diphenhydramine hydrochloride, cetirizine dihydrochloride
and rupatadine resulted in significant suppression of contraction
responses to histamine stimulation (Figure 4D).