Peanut OIT suppresses allergen-specific responses
As a promising treatment option for FA, the suppression of allergic
responses following OIT was also investigated using the PCIS model. PCIS
passively sensitized with plasma from a peanut allergic individual
pre-peanut OIT, stimulated with PE resulted in a strong smooth muscle
contraction response (Figure 5). Following completion of the OIT
protocol, plasma from the same individual resulted in a diminished
response after stimulation with PE, which is reflective of the clinical
phenotype of the plasma donor. Co-incubation of pre- and post-OIT plasma
also resulted in a reduced contraction response in comparison to the
pre-OIT condition, reflecting the sensitivity of the model (Figure 5).