3.5 Late serum markers of cisplatin-induced acute kidney injury
Serum metabolites that were significantly different between AKI and no
AKI were predominantly elevated in the AKI group (Figure 5 ),
with the exception of glutamine, which was 1.55-fold lower in AKI
patients at the post timepoint (Table 2 , Figure 5B ).
Serum levels of creatinine (↑1.81-fold), linolenic acid (↑1.97-fold),
octenoylcarnitine (↑2.09-fold), octanoylcarnitine (↑2.46-fold), indoxyl
sulfate (↑2.87-fold), and N,N,N-trimethyl-L-alanyl-L-proline betaine
(TMAP, ↑1.87-fold) were significantly higher in AKI patients at the post
timepoint compared to no AKI patients (Table 2, Figure 5A,
5C-5G ). AUROC values for all serum metabolites at the post timepoint
were greater than 0.7, with octenoylcarnitine and TMAP having AUROC
> 0.8, and creatinine, octanoylcarnitine, and indoxyl
sulfate AUROC values > 0.9 (Figure 5H ).
Additionally, the AUROC values of ocanoylcarnitine at the pre timepoint
and indoxyl sulfate and TMAP at the 24-48h timepoint were greater than
0.7, though the differences were not statistically significant
(Figure 5H ).