3.4 Late urinary markers of cisplatin-induced acute kidney
injury
Aminoisobutanoate (↓4.69-fold), betaine (↓2.67-fold), glutamine
(↓1.98-fold), glycolate (↓2.71-fold), histidine (↓2.63-fold),
indole-3-acetate (↓4.03-fold), serine (↓2.80-fold), taurine
(↓2.56-fold), threonine (↓2.90), and tyramine (↓2.87-fold) were all
significantly lower at the post timepoint in the AKI group relative to
the no AKI group (Table 2 , Figure 4 ). With the
exception of aminoisobutanoate, all of the aforementioned metabolites
exhibited AUROC ≥ 0.8 at the post timepoint, with AUROC of glycolate and
tyramine being greater than 0.9 (Figure 4H). Though not
statistically significant, betaine, indole-3-acetate, and threonine
trended lower in AKI patients compared to no AKI patients at the pre
timepoint with AUROC values ≥ 0.7 (Figure 4B, 4F, 4I ).
Similarly, urine levels of aminoisobutanoate, indole-3-acetate, and
tyramine trended lower in AKI patients at the 24-48h timepoint with
AUROC ≥ 0.7, though the difference was not statistically significant
(Figure 4A, 4F, 4J ).