References:
- Al-Hakeim, H.K., Al-Rammahi, D.A., Al-Dujaili, A.H., 2015. IL-6,
IL-18, sIL-2R, and TNFα proinflammatory markers in depression and
schizophrenia patients who are free of overt inflammation. J Affect
Disord. 15,106-14. http://doi.org/10.1016/j.jad.2015.04.044.
- Bacchiega, B.C., Bacchiega, A.B., Usnayo, M.J.G., Bedirian, R., Singh,
G., Pinheiro, G.D.C. 2017. Interleukin 6 Inhibition and Coronary
Artery Disease in a High-Risk Population: A Prospective
Community-Based Clinical Study. Am Heart J. 6,
1-9.http://doi.org/10.1161/JAHA.116.005038
- Ballak, D.B., Stienstra, R., Tack, C.J., Dinarello, C.A., van Diepen,
J.A., 2015. IL-1 family members in the pathogenesis and treatment of
metabolic disease: Focus on adipose tissue inflammation and insulin
resistance. Cytokine. 75, 280-90.
http://doi.org/10.1016/j.cyto.2015.05.005.
- Barnard, D.F., Gabella, K.M., Kulp, A.C., Parker, A.D., Dugan, P.B.,
Johnson, J.D., 2019. Sex differences in the regulation of brain IL-1β
in response to chronic stress. Psychoneuroendocrinology.103, 203-211.
http:// doi.org/ 10.1016/j.psyneuen.2019.01.026.
- Beurel, E., Toups, M., Nemeroff, C.B., 2020. The Bidirectional
Relationship of Depression and Inflammation: Double Trouble. Neuron.
107, 234-256. http://doi.org/10.1016/j.neuron.2020.06.002.
- Bhatt, S., Devadoss, T., Jha, N. K., Baidya, M., Gupta, G.,
Chellappan, D. K., Singh, S. K., Dua, K., 2022. Targeting
inflammation: a potential approach for the treatment of
depression. Metab brain dis.
https://doi.org/10.1007/s11011-022-01095-1
- Bhatt, S., Mahesh, R., Devadoss, T., Jindal, A., 2017.
Neuropharmacological evaluation of a novel 5-HT3 receptor antagonist
(4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl) methanone (6 g) on
lipopolysaccharide-induced anxiety models in mice. J Basic Clin
Physiol Pharmacol. 28, 101–106.
http://doi.org/10.1515/jbcpp-2016-0083.
- Birur, B., Amrock, E.M., Shelton, R.C., Li, L., 2017. Sex Differences
in the Peripheral Immune System in Patients with Depression. Front
psychiatry. 8, 108. https://doi.org/10.3389/fpsyt.2017.00108
- Brambilla, F., Monteleone, P., Maj, M., 2004. Interleukin-1beta and
tumor necrosis factor-alpha in children with major depressive disorder
or dysthymia. J Affect Disord. 78, 273-7.
http://doi.org/10.1016/S0165-0327(02)00315-4.
- Brown, T.A., Korotitsch, W., Chorpita, B.F. Barlow, D.H.,
1997. Psychometric properties of the Depression Anxiety Stress Scales
(DASS) in clinical samples. Behav Res and Ther, 35, 79-89.
https://doi.org/10.1348/014466506X158996
- Buckley, L.F., Abbate, A., 2018. Interleukin-1 blockade in
cardiovascular diseases: a clinical update. Eur. Heart J. 39,
2063–2069. http://doi.org/10.1093.
- Bürhan-Çavuşoğlu,
P., İscan, E., Güneş, A., Atabey, N., Alkın, T., 2021. Increased
telomerase activity in major depressive disorder with melancholic
features: Possible role of pro-inflammatory cytokines and the
brain-derived neurotrophic factor. Brain Behav Immun Health. 4:100259.
http://doi.org/10.1016/j.bbih.2021.100259.
- Capuron, L., Fornwalt, F.B., Knight, B.T., Harvey, P.D., Ninan, P.T.,
Miller, A.H., 2009. Does cytokine-induced depression differ from
idiopathic major depression in medically healthy individuals?. J
Affect disord. 119, 181–185.
https://doi.org/10.1016/j.jad.2009.02.017
- Cassano, P., Bui, E., Rogers, A.H., Walton, Z.E., Ross, R., Zeng, M.,
Nadal-Vicens, M., Mischoulon, D., Baker, A.W., Keshaviah, A.,
Worthington, J., Hoge, E.A., Alpert, J., Fava M., Wong, K.K., Simon
,N.M., 2017. Inflammatory cytokines in major depressive disorder: A
case-control study. Aust N Z J Psychiatry. 51, 23-31.
http://doi.org/10.1177/0004867416652736.
- Castro, J.P., El-Atat, F.A., McFarlane, S.I., Aneja, A., Sowers, J.R.,
2003. Cardiometabolic syndrome: pathophysiology and treatment. Curr
Hypertens Rep.5, 393-401. http://doi.org/ 10.1007/s11906-003-0085-y.
- Celano, C.M., Huffman, J.C., 2011. Depression and cardiac disease: a
review. Cardiol Rev.19,130-42. http://doi.org/
10.1097/CRD.0b013e31820e8106.
- Cilan, H., Oguzhan, N., Unal, A., Turan, T., Koc, A.N., Sipahioglu,
M.H., Utas, C., Oymak, O., 2012. Relationship between depression and
proinflammatory cytokine levels in hemodialysis patients. Ren Fail.
34, 275-8. http://doi.org/ 10.3109/0886022X.2011.647292.
- Dahl, J., Ormstad, H., Aass, H.C., Malt, U.F., Bendz, L.T., Sandvik,
L., Brundin, L., Andreassen, O.A., 2014. The plasma levels of various
cytokines are increased during ongoing depression and are reduced to
normal levels after recovery. Psychoneuroendocrinology. 45, 77-86.
http://doi.org/ 10.1016/j.psyneuen.2014.03.019.
- Dantzer, R., O’Connor, J.C., Freund, G.G., Johnson, R.W., Kelley,
K.W., 2008. From inflammation to sickness and depression: when the
immune system subjugates the brain. Nat. Rev. Neurosci. 9, 46–56.
http://doi.org/10.1038/nrn2297
- Davidson, K.W., Schwartz, J.E., Kirkland, S.A., Mostofsky, E., Fink,
D., Guernsey, D., Shimbo, D., 2009. Relation of inflammation to
depression and incident coronary heart disease (from the Canadian Nova
Scotia Health Survey [NSHS95] Prospective Population Study). Am J
Cardiol. 103, 755-61. http://doi.org/10.1016/j.amjcard.2008.11.035.
- Derogatis, L.R., 1975. Brief Symptom Inventory. Baltimore, MD: Clin.
Psychom. Res.
- Dinarello, C.A., 2018. Overview of the IL-1 family in innate
inflammation and acquired immunity. Immunol Rev. 281, 8-27.
http://doi.org/10.1111/imr.12621.
- Dorrance, A.M., 2007. Interleukin 1-beta (IL-1beta) enhances
contractile responses in endothelium-denuded aorta from hypertensive,
but not normotensive, rats. Vascul Pharmacol. 47, 160-5.
http://doi.org/10.1016/j.vph.2007.05.007.
- Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim,
E.K., Lanctôt, K.L., 2010. A meta-analysis of cytokines in major
depression. Biol Psychiatry. 67, 446-57.
http://doi.org/10.1016/j.biopsych.2009.09.033.
- Elgellaie, A., Larkin, T., Kaelle, J., Mills, J., Thomas, S., 2021.
Plasma prolactin is higher in major depressive disorder and females,
and associated with anxiety, hostility, somatization, psychotic
symptoms and heart rate. Comprehensive Psychoneuroendocrinology, 6.
http://doi.org/10.1016/j.cpnec.2021.100049.
- Felger, J.C., and Lotrich, F.E., 2013. Inflammatory Cytokines in
Depression: Neurobiological Mechanisms and Therapeutic Implications.
Neurosci. 246, 199-229.
https://doi.org/10.1016/j.neuroscience.2013.04.060
- Finnell, J.E., Wood, S.K., 2016. Neuroinflammation at the interface of
depression and cardiovascular disease: Evidence from rodent models of
social stress. Neurobiol Stress. 4, 4:1-14.
https://doi.org/10.1016/j.ynstr.2016.04.001.
- Gao, Z., Chen, Z., Sun, A., Deng, X. 2019. Gender differences in
cardiovascular disease. DOAJ.4.
https://doi.org/10.1016/j.medntd.2019.100025.
- Global Burden of Disease, 2017. Global, regional, and national
incidence, prevalence, and years lived with disability for 354
diseases and injuries for 195 countries and territories, 1990–2017: a
systematic analysis for the Global Burden of Disease Study 2017. The
Lancet. 392, 1789-1858.
- Goldbacher, E., Matthews, K. A., 2007. Are psychological
characteristics related to risk of the metabolic syndrome? A review of
the literature. Ann Behav Med. 34, 240–52. doi:10.1007/BF02874549
- Gowey, M.A., Khodneva, Y., Tison, S.E., Carson, A.P., Cherrington,
A.L., Howard, V.J., Safford, M.M., Dutton, G.R., 2019. Depressive
symptoms, perceived stress, and metabolic health: The REGARDS study.
Int J Obes (Lond). 43, 615-632.
https://doi.org/10.1038/s41366-018-0270-3.
- Hersey, M., Hashemi, P., Reagan, L. P. 2022. Integrating the monoamine
and cytokine hypotheses of depression: Is histamine the missing
link?. Eur. J. Neurosci. 55 , 2895–2911.
https://doi.org/10.1111/ejn.15392.
- Hueston, C.M., Deak, T., 2014. The inflamed axis: the interaction
between stress, hormones, and the expression of inflammatory-related
genes within key structures comprising the
hypothalamic-pituitary-adrenal axis. Physiol Behav.124, 77-91.
https://doi.org/10.1016/j.physbeh.2013.10.035.
- Karlović, D., Serretti, A., Vrkić, N., Martinac, M., Marčinko, D.,
2012. Serum concentrations of CRP, IL-6, TNF-α and cortisol in major
depressive disorder with melancholic or atypical features. Psychiatry
Res. 198, 74-80. https://doi.org/10.1016/j.psychres.2011.12.007.
- Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R.,
Walters, E.E., 2005. Lifetime prevalence and age-of-onset
distributions of DSM-IV disorders in the National Comorbidity Survey
Replication. Arch Gen Psychiatry. 62, 593-602.
https://doi.org/10.1001/archpsyc.62.6.593.
- Klein, S., Flanagan, K., 2016. Sex differences in immune
responses. Nat Rev Immunol. 16, 626–638.
https://doi.org/10.1038/nri.2016.90
- Köhler, C.A., Freitas, T.H.,
Maes, M., de Andrade, N.Q., Liu, C.S., Fernandes, B.S., Stubbs, B.,
Solmi, M., Veronese, N., Herrmann, N., Raison, C.L., Miller, B.J.,
Lanctôt, K.L., Carvalho, A.F., 2017. Peripheral cytokine and chemokine
alterations in depression: a meta-analysis of 82 studies. Acta
Psychiatr Scand. 135,373-387. https://doi.org/10.1111/acps.12698.
- Kornstein, S.G., Schatzberg, A.F., Thase, M.E., Yonkers, K.A.,
McCullough, J.P., Keitner, G.I., Gelenberg, A.J., Davis, S.M.,
Harrison, W.M., Keller, M.B., 2000. Gender differences in treatment
response to sertraline versus imipramine in chronic depression. Am J
Psychiatry. 157, 1445-52. http://doi.org/10.1176/appi.ajp.157.9.1445.
- Liu, Y., Ho, R.C., Mak, A., 2012. Interleukin (IL)-6, tumour necrosis
factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are
elevated in patients with major depressive disorder: a meta-analysis
and meta-regression. J Affect Disord. 139, 230-9.
http://doi.org/10.1016/j.jad.2011.08.003.
- Lovibond, S.H., Lovibond, P.F., 1995. Manual for the Depression
Anxiety Stress Scales. (2nd. Ed.) Sydney: Psychology
Foundation. ISBN 7334-1423-0.
- Maes, M., Kubera, M., Obuchowiczwa, E., Goehler, L., Brzeszcz, J.,
2011. Depression’s multiple comorbidities explained by
(neuro)inflammatory and oxidative & nitrosative stress pathways.
Neuro Endocrinol Lett. 32, 7-24. PMID: 21407167.
- Matthews, K.A., Salomon, K., 2003. Hostility predicts the metabolic
syndrome risk factors in children and adolescents. Health Psychol. 22,
279–286.
http://doi.org/10.4306/pi.2014.11.3.325
- McEwen, B.S., 2008. Central effects of stress hormones in health and
disease: Understanding the protective and damaging effects of stress
and stress mediators. Eur J Pharmacol.583, 174-185.
http://doi.org/10.1016/j.ejphar.2007.11.071
- Munjiza, A., Kostic, M., Pesic, D., Gajic, M., Markovic, I., Tosevski,
D.L., 2018. Higher concentration of interleukin 6 - A possible link
between major depressive disorder and childhood abuse. Psychiatry Res.
264, 26-30. http://doi.org/10.1016/j.psychres.2018.03.072.
- Nabi, H., Hall, M., Koskenvuo, M., Singh-Manoux, A., Oksanen, T.,
Suominen, S., Kivimäki, M. M., Vahtera, J., 2010. Psychological and
Somatic Symptoms of Anxiety and Risk of Coronary Heart Disease: The
Health and Social Support Prospective Cohort Study. Biol Psychiatry.
67, 378–385 http://doi.org/10.1016/j.biopsych.2009.07.040.
- Obermanns, J., Krawczyk, E., Juckel, G., Emons, B. 2021. Analysis of
cytokine levels, T regulatory cells and serotonin content in patients
with depression. Eur. J. Neurosci. 53 , 3476–3489.
https://doi.org/10.1111/ejn.15205
- O’Connor, M.F., Motivala, S.J., Valladares, E.M., Olmstead, R., Irwin,
M.R., 2007. Sex differences in monocyte expression of IL-6: role of
autonomic mechanisms. Am J Physiol Regul Integr Comp Physiol. 293,
R145-51. http://doi.org/10.1152/ajpregu.00752.2006.
- Ojike, N., Sowers, J. R., Seixas, A., Ravenell, J.,
Rodriguez-Figueroa, G., Awadallah, M., Zizi, F., Jean-Louis, G.,
Ogedegbe, O., Samy I. McFarlane, S. I., 2016. Psychological Distress
and Hypertension: Results from the National Health Interview Survey
for 2004–2013. Cardiorenal Med. 6, 198–208.
http://doi.org/0.1159/000443933.
- Olafiranye, O., Jean-Louis, G., Zizi, F., Nunes, J., Vincent, M.,
2011. Anxiety and cardiovascular risk: Review of Epidemiological and
Clinical Evidence. Mind & brain : the journal of psychiatry, 2,
32–37.
- Osimo, E.F., Pillinger, T., Rodriguez, I.M., Khandaker, G.M.,
Pariante, C.M., Howes, O.D., 2020. Inflammatory markers in depression:
A meta-analysis of mean differences and variability in 5,166 patients
and 5,083 controls. Brain Behav Immun. 87, 901-909.
http://doi.org/10.1016/j.bbi.2020.02.010.
- Pittig. A., Arch, J.J., Lam, C.W., Craske, M.G., 2013. Heart rate and
heart rate variability in panic, social anxiety, obsessive-compulsive,
and generalized anxiety disorders at baseline and in response to
relaxation and hyperventilation. Int J Psychophysiol. 87, 19-27.
http://doi.org/10.1016/j.ijpsycho.2012.10.012
- Postal, M., Lapa, A. T., Sinicato, N. A., de Oliveira Peliçari, K.,
Peres, F. A., Costallat, L. T., Fernandes, P. T., Marini, R.,
Appenzeller, S., 2016. Depressive symptoms are associated with tumor
necrosis factor alpha in systemic lupus erythematosus. J.
neuroinflammation, 13, 5.
https://doi.org/10.1186/s12974-015-0471-9
- Quitkin, F.M., Stewart, J.W., McGrath, P.J., Taylor, B.P.,
Tisminetzky, M.S., Petkova, E., Chen, Y., Ma, G., Klein, D. F. 2002.
Are there differences between women’s and men’s antidepressant
responses? Am J Psychiatry. 159, 1848–1854.
https://doi.org/10.1176/appi.ajp.159.11.1848
- Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag,
A., Pollmächer, T., 2001. Cytokine-associated emotional and cognitive
disturbances in humans. Arch Gen Psychiatry. 58 :445-52.
https://doi.org/10.1001/archpsyc.58.5.445.
- Ridker, M., Rane, M., 2021. Interleukin-6 Signaling and
Anti-Interleukin-6 Therapeutics in Cardiovascular Disease. Circ
res. 128, 1728–1746. https://doi.org/10.1161/CIRCRESAHA.121.319077
- Ridker, P.M., Hennekens, C.H., Buring, J.E., Rifai, N., 2000.
C-reactive protein and other markers of inflammation in the prediction
of cardiovascular disease in women. N Engl J Med. 342, 836-43.
https://doi.org/10.1056/NEJM200003233421202.
- Schmidt, F.M., Lichtblau, N., Minkwitz, J., Chittka, T., Thormann, J.,
Kirkby, K.C., Sander, C., Mergl, R., Faßhauer, M., Stumvoll, M.,
Holdt, L.M., Teupser, D., Hegerl, U., Himmerich, H., 2014. Cytokine
levels in depressed and non-depressed subjects, and masking effects of
obesity. J Psychiatr Res. 55, 29-34.
http://doi.org/10.1016/j.jpsychires.2014.04.021.
- Seney, M.L., Glausier, J., Sibille, E., 2021. Large-Scale
Transcriptomics Studies Provide Insight Into Sex Differences in
Depression. Biol Psychiatry.
http://doi.org/10.1016/j.biopsych.2020.12.025.
- Sheehan, D.V., 2015. Mini International Neuropsychiatric Interview
7.0. FL: Medical Outcomes Systems. Jacksonville.
- Shelton, R.C., Falola, M., Li, L., Zajecka, J., Fava, M., Papakostas,
G. I., 2015. The pro-inflammatory profile of depressed patients is
(partly) related to obesity. J psychiatr. Res. 70, 91–97.
https://doi.org/10.1016/j.jpsychires.2015.09.001
- Simon, G.E., Ludman, E.J., Linde, J.A., Operskalski, B.H., Ichikawa,
L., Rohde, P., Finch, E.A., Jeffery, R.W., 2007. Association between
obesity and depression in middle-aged women. Gen Hosp Psychiatry. 30,
32-9. http://doi.org/10.1016/j.genhosppsych.2007.09.001.
- Spicer, J., Chamberlain. K., 1996. Cynical hostility, anger, and
resting blood pressure. J Psychosom Res. 40, 359-68.
http://doi.org/10.1016/0022-3999(95)00546-3.
- Srivastava, A.K., 2012. Challenges in the treatment of cardiometabolic
syndrome. Indian J. pharmacol. 44, 155–156.
https://doi.org/10.4103/0253-7613.93579.
- Suarez, E.C., Bates, M.P., Harralson, T.L., 1998. The relation of
hostility to lipids and lipoproteins in women: evidence for the role
of antagonistic hostility. Ann Behav Med. 20, 59-63.
https://doi.org/10.1007/BF02884449.
- Suarez, E.C., Krishnan, R.R., Lewis, J. G., 2003. The Relation of
Severity of Depressive Symptoms to Monocyte-Associated Proinflammatory
Cytokines and Chemokines in Apparently Healthy Men, Psychosom. Med.
65, 362-368. https://doi.org/10.1097/01.PSY.0000035719.79068.2B
- Suarez, E.C., Lewis, J.G., Krishnan, R.R., Young, K.H., 2004. Enhanced
expression of cytokines and chemokines by blood monocytes to in vitro
lipopolysaccharide stimulation are associated with hostility and
severity of depressive symptoms in healthy women.
Psychoneuroendocrinology. 29,1119-28.
https://doi.org/10.1016/j.psyneuen.2004.01.002.
- Takahashi, A., Flanigan, M.E., McEwen, B.S., Russo, S.J., 2018.
Aggression, Social Stress, and the Immune System in Humans and Animal
Models. Front Behav Neurosci. 22,12:56.
https://doi.org/10.3389/fnbeh.2018.00056.
- Tuglu, C., Kara, S.H., Caliyurt, O., Vardar, E., Abay, E., 2003.
Increased serum tumor necrosis factor-alpha levels and treatment
response in major depressive disorder. Psychopharmacology (Berl). 170,
429-33. https://doi.org/10.1007/s00213-003-1566-z.
- Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang,
A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., Cella, D.,
Krishnan, R., 2006. Etanercept and clinical outcomes, fatigue, and
depression in psoriasis: double-blind placebo-controlled randomised
phase III trial. Lancet. 367, 29-35.
https://doi.org/10.1016/S0140-6736(05)67763-X.
- Um, J.Y., Rim, H.K., Kim, S.J., Kim, H.L., Hong, S.H., 2011.
Functional polymorphism of IL-1 alpha and its potential role in
obesity in humans and mice. PLoS One. 6.
https://doi.org/10.1371/journal.pone.0029524.
- Urschel, K., Cicha, I., 2015. TNF-α in the cardiovascular system: from
physiology to therapy. Int. J. Interferon, Cytokine Mediat. Res. 7,
9-25. https://doi.org/10.2147/IJICMR.S64894
- Voronov, E., Dotan, S., Krelin, Y., Song, X., Elkabets, M., Carmi, Y.,
Rider, P., Idan, C., Romzova, M., Kaplanov, I., Apte, R.N., 2013.
Unique Versus Redundant Functions of IL-1α and IL-1β in the Tumor
Microenvironment. Front Immunol. 8, 4:177.
https://doi.org/10.3389/fimmu.2013.00177.
- Wegner, A., Benson, S., Rebernik, L., Spreitzer, I., Jäger, M.,
Schedlowski, M., Elsenbruch, S., Engler, H., 2017. Sex differences in
the pro-inflammatory cytokine response to endotoxin unfold in vivo but
not ex vivo in healthy humans. Innate Immun. 23, 432-439.
https://doi.org/10.1177/1753425917707026.
- Wong, J.M., Na, B., Regan, M.C., Whooley, M.A., 2013. Hostility,
health behaviors, and risk of recurrent events in patients with stable
coronary heart disease: findings from the Heart and Soul Study. J Am
Heart Assoc. 2, e000052. https://doi.org/10.1161/JAHA.113.000052.
- World Health Organisation, 2017. Cardiovascular diseases. Available
at: http://www.who.int/mediacentre/factsheets/fs317/en/ (09 June
2021, date last accessed).