Blood Sampling
For both fasting and fed conditions, peripheral venous blood samples (approximate 4 mL) from each subject were drawn at 0 hour (within 60min pre-dose), 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 10, 12, 24, 48, 72, 96,120, 144, and 168 hours post-administration in K2EDTA anticoagulated tubes, mixed upside down gently, and transferred in ice-water bath. Sample were centrifuged at 3500 rpm at 2-8 ℃ for 10 minutes, and supernatant plasma was equally pipetted into assay parts and backup parts. All plasma samples were stored in ultra-low temperature refrigerators (-80 ℃). All blood samples were centrifuged within 30 min after collection, and the plasma samples were frozen within 1 hours after centrifugation.