Ethics
This study was approved and performed at the Beijing Chao-Yang hospital,
Capital Medical University (BCYH-CMU). The study protocol and informed
consent form were endorsed by the BCYH-CMU Ethics Committee with the
ethical approval number 2017-drug-2 (April 10, 2017). This clinical
study was implemented according to Good Clinical Practice and the
Declaration of Helsinki, International Council for Harmonization
Guidelines. Besides, this study was registered at the website of
Clinical Trial Registry (Identifier: CTR20180968,
http://www.chinadrugtrials.org.cn) and was conducted from July 2018.