Population (Patient/Control)
SNP
Location
Genotypes
Odds Ratio
P value
VDR variation and PD risk
Reference
Korean Population (137/163)
TaqI
rs731236
TT
1.000
0.012
Risk of PD significantly increased
[26]
TC/CC 0.816
25-OH vitamin D3 level 0.872
Interaction 1.122
BsmI rs1544410 GG 1.000 0.017 Risk of PD significantly increased
GA/AA 0.636
25-OH vitamin D3 level 0.873
Interaction 1.117
ApaI rs7976091 CC 1.000 0.867 The risk of PD did not increase significantly
CC/TT 1.276
25-OH vitamin D3 level 0.885
Interaction 1.007
FokI rs2228570 CC 1.000 0.541 The risk of PD did not increase significantly
CC/TT 1.593
25-OH vitamin D3 level 0.904
Interaction 0.977
Japanese population 137/none FokI 25OHD 0.93 0.001 Both independently and in interaction, FokI CC increases PD risk. [32]
CC 0.32 0.002
Interaction 0.34 0.17