Statistical analysis
Differences between continuous variables were tested for significance using the independent-samples t -test. Differences between categorical variables were tested for significance using the chi-squared test or Fisher’s exact test, each as appropriate. All tests applied were two-tailed and a P -value ≤0.05 was considered statistically significant. Survival was analysed with Kaplan-Meier plots. Median survival durations were reported with 95% confidence intervals (CI). Differences between groups were tested using the Log-Rank test. The data were analysed using R version 4.0.5 (R Foundation for Statistical Computing, Vienna, Austria).