Statistical Analysis
Data were analyzed using IBM SPSS Statistics 21.0. Categorical variables were represented as number and percentage, continuous numerical variables were represented as mean, standard deviation, minimum and maximum values. Distribution analysis was done by the Shapiro-Wilk method. Parametric data were compared with Spearman correlation test and nonparametric data with Wilcoxon test. p < 0.05 was considered to indicate statistical significance.
Results
The characteristics of the pregnant women are given in Table 1. Sixty-eight percent of women had comorbidities. The major comorbidity was gestational diabetes and hypothyroidism (26% and 22% of women, respectively). Ten percent of women had pregestational hypertension. The other comorbidities were coronary artery disease and chronic kidney disease. All of the women were on antihypertensive medication. Laboratory work-up of the pregnants are shown in Table 2.
Ultrasound finding of the fetuses and gestationa age are given in Table 3. Mean umbilical artery systolic/diastolic ratio, umbilical artery pulsatility index and median cerebral artery pulsatility index were 3.1 ± 1.05, 1.18 ± 0.16 and 1.32 ± 0.13, respectively.
Eighty-two percent of the women had a Cesarean section. The mean APGAR scores at one and five minutes were 6.1 and 7.9, respectively.
The magnesium serum levels before and after magnesium sulfate prophylaxis are shown in Table 4. The increase in magnesium serum levels after seizure prophylaxis was 2.6 mg/dL and 0.07 in MPI (Figure 1).
There were no correlations between MPI difference and age, BMI, gravida, parity, abortus, hemoglobin, thrombocyte count, white blood cell count, liver function tests, creatinine, fibrinogen, INR, gestational week, biparietal diameter, head circumference, abdominal circumference, femur length, umbilical artery SD, PI, RI, middle cerebellar artery peak systolic velocity, APGAR scores, or serum magnesium level difference.