3.3.4 Pooled safety outcomes
Common perioperative complications include cardiac effusion, cardiac
tamponade, Device migration, Device thrombus, Stroke/TIA, bleeding,
hematoma, renal complications, cardiac arrest, death, et al. The data on
procedural complications was available in nine clinical
studies[6-8, 10-15].Complications from each study
are listed independently in Supplementary Table 5 andSupplementary Table 6 . The rate of procedural complications in
ICE group is similar to that of TEE group (RR:0.82; 95%CI: 0.58,1.16;P =0.261; I²=23.50%) (Figure 8 ). Sensitivity analysis
was performed and the results showed no significant change in the
overall combined proportion, ranging from 0.70 (95%CI:0.45,1.10) to
0.87 (95%CI:0.61,1.25). Egger’s test also showed no publication bias
(P =0.696). Meanwhile, seven clinical studies were followed up and
reported long-term adverse events [6-11, 14]. In
terms of long-term adverse events, the ICE group showed a similar result
to TEE group (RR=0.86; 95%CI: 0.64,1.16; P =0.329; I²=41.10%)
(Figure9 ).