Dealing with missing data. We carefully considered the implications of missing individual participant outcome data (due to loss to follow-up or exclusions from analysis). Important numerical data, such as selected and randomized participants, as well as ITT or per-protocol analysis (PP), was carefully evaluated. In addition, losses to follow-up will be assessed and questions related to missing data will be critically appraised. Guessing about the results of participants who were lost was avoided. Whenever possible, we have contacted the authors of the different clinical trials to try to complete the incomplete information. When missing data were considered to affect the final result, the study was excluded from the meta-analysis. A sensitivity analysis is planned to assess how sensitive the results are to reasonable changes in the assumptions considered. We also plan to address the potential impact of missing data on the review findings in the Discussion section.