We plan to perform a sensitivity analysis to assess the robustness of the results, such as the impact of assumptions, imputed data, borderline decisions, and clinical trials with a high risk of bias. Therefore, sensitivity analysis was carried out taking into consideration: a) low risk of bias studies and high risk of bias studies; b) random effects vs. fixed effects; c) RR vs. Odds Ratio (OR)
In the overall judgment of the risk of bias, trials were considered to be at high risk of bias if these were at high risk in at least one domain for this result or were judged to have some concerns across multiple domains. We present the results in the random-effect model (RE), which will default to a fixed model when there is a lack of heterogeneity
FINDINGS