Measures of treatment effect. We will follow the intention-to-treat (ITT) principle, to assess the effect of intervention allocation, and maintain the benefit of the randomization, regardless of whether the interventions are received as intended. Dichotomous outcomes were analyzed by risk ratio calculation (RR), while for continuous outcomes we estimated the mean difference (MD). We calculate each summary measure’s corresponding confidence interval of 95% (IC 95%). We will use the standardized mean difference (SMD) when studies use different instruments. As an absolute measure, the Number Needed to Treat (NNT) will be determined as the inverse of the Absolute Risk Reduction (1/ARR). We consider the possibility and implications of skewed data when analyzing continuous outcomes, particularly in small sample trials, where the true distribution may be asymmetrical