The search strategy was agreed upon by the authors and replicable, obtaining all relevant studies. The review was done in duplicate to establish the eligibility of the studies. Two researchers were involved in screening (ODS, CDN) using the Covidence tool (https://www.covidence.org). We use Medeley Cite (https://mendeley.com) as software to manage references. An exhaustive search of the scientific literature was carried out in each of the following databases from the beginning of the report until November 2023, identifying RCTs that evaluated the efficacy of varenicline for the treatment of people with AUD regardless of its publication status: PubMed (https://PubMed.ncbi.nlm.nih.gov), Cochrane Library (https://www.cochranelibrary.com/), SciELO (https://SciELO.org/es/), Science Direct (https://www.ScienceDirect.com/), Google Scholar (https://scholar.google.com/) Europe PMC (https://europepmc.org/), Trip Database (https://www.tripdatabase.com/), LILACS (https://LILACS.bvsalud.org/es/) and Index Medicus for South-East Asia Region, IMSEAR (https://imsear.searo.who.int/handle/123456789/205654)