We plan to perform a sensitivity analysis to assess the
robustness of the results, such as the impact of assumptions, imputed
data, borderline decisions, and clinical trials with a high risk of
bias. Therefore, sensitivity analysis was carried out taking into
consideration: a) low risk of bias studies and high risk of bias
studies; b) random effects vs. fixed effects; c) RR vs. Odds Ratio
(OR)
In the overall judgment of the risk of bias, trials were considered to
be at high risk of bias if these were at high risk in at least
one domain for this result or were judged to have some concerns across
multiple domains. We present the results in the random-effect
model (RE), which will default to a fixed model when there is a lack of
heterogeneity
FINDINGS