Need and amount of vasopressor agents. Regarding the need for vasopressors, pooling the four RCTs (39) (40) (41) (42), an RR of 0.79 (95% CI= 0.51 to 1.21) was obtained, with a considerable heterogeneity (I2=89%). In one of the studies the need for vasoactive agents was not predefined as outcomes and the authors reported that all participants eventually required vasopressors (42). Following a sensitivity analysis, excluding this trial, and pooling the remaining RCTs deliver a RR of 0.76 (95%CI= 0.61 to 0.94) with negligible heterogeneity (I2 = 1%), shown in Figure 10 (Forest plot of comparison: Sensitivity analysis, outcome 1.4 Need for vasopressors agents). Concerning the amount of vasopressors, only two clinical trials reported this outcome. (40) (42). In one of the RCTs (40), the total amount (mg) was significantly lower in the paraffin oil group compared to the control group (mean of 46.5 ± 16.7 mg vs. 68.4 ± 25.4 mg respectively; p= 0.016). On the contrary, in the other trial, the amounts were higher in the intervention group, but with no significant difference (42). Contradictory results have been attributed to the higher rate of morality in the control group.