Trials
Study design
Participants and Interventions
Amount ingested
Risk of bias and Comments
Sanagoo 2013 (37) (Iran, from March to July) Unpublished RCT Single-blind 2 parallel-group Patients of any age of both genders, with acute AlP poisoning (N= 66) within the first 3 h of exposition All people received standard treatment -Group I: Coconut oil (N=33) -Group II: Control group (N=33) Mean Group I: 2.6 Group II: 2.3 The diagnosis was not biochemically validated. Random sequence generation and allocation concealment were not detailed AEs were not reported as a specific outcome
Dayananda 2018 (38) (India, from March 2014 to August 2016) RCT ¿? 2 parallel groups Adults of both sexes, with acute AlP poisoning (N= 50). All people received standard treatment -Group I: Coconut oil -Group II: Control group Mean Group I: 2.24 Group II: 2.48 Blinding, random sequence generation and allocation concealment were not detailed AEs were not reported as a specific outcome
Darwish 2020 (39) (Egypt, between June 2018 and May 2019) RCT Double-blind 3 parallel groups Patients aged more than 18 years of both genders, with acute AlP poisoning within the first 6 h of exposition (N= 90). All people received standard treatment -Group I: KMNO4 solution (1:10 000) This group was a historical control (N=30) -Group II: Paraffin oil (N=30) -Group III: Co Q10 + Paraffin oil (N=30) Mean (SD) Group I: 0.97 ± 0.50 Group II: 0.83 ± 0.36 Group III: 1.15 ± 0.73 The diagnosis was not biochemically validated. The allocation concealment method was not described. AEs were not reported as a specific outcome.
Helal 2022 (40) (Egypt 2020, from June to November) RCT Single-blind 2 parallel-group (Phase 2) Patients aged more than 18 years of both genders, with acute AlP poisoning within the first 0.5 to 2.5 h of exposition (N= 62). All people received standard treatment -Group I (N=31): Paraffin oil -Group II (N=31): Control group Mean (SD) Group I: 1.1 ± 0.18 Group II: 1.3 ± 0.43 This was a single-blind study, and the outcomes are likely to be influenced by the lack of blinding AEs were not reported as a specific outcome
Abdelhamid 2023 (41) (Egypt, from January to December 2020) RCT Single-blind 3 parallel groups Adults of both sexes, with acute AlP poisoning within the first 6 hs of exposition (N=96). All people received standard treatment -Group I (N=32): N-acetyl cysteine (NAC) -Group II (N=32): NAC + L- carnitine -Group III (N=32): NAC + Paraffin oil Mean (SD) Group I: 1.47 ± 0.8 Group II: 1.47 ± 0.6 Group III: 1.8 ± 0.6 The diagnosis was not biochemically validated This was a single-blind study, and the outcomes are likely to be influenced by the lack of blinding AEs were not reported as a specific outcome
Elbastawesy 2023 (42) (Egypt between January, and June 2021) RCT Double-blind 3 parallel groups Patients aged more than 12 years of both genders, with acute AlP poisoning within the first 2 h of exposition (N= 60). All people received standard treatment -Group I (N=20): Paraffin oil -Group II (N=20): Coconut oil -Group III (N=20): Control group Mean (SD) Group I: 1.0 ± 0 Group II: 0.83 ± 0.4 Group III: 0.83 ± 0.4 This was the trial rated with the lowest risk of bias AEs were reported as a specific outcome
Elsharkawy 2023 (43) (Egypt, between December to November 2021) RCT Single-blind 3 parallel groups (Phase 2) Patients aged more than 18 years of both genders, with acute AlP poisoning within the first 6 h of exposition (N= 84). All people received standard treatment -Group I (N=28): Control group -Group II (N=28): Coconut oil -Group III (N=28): Coconut oil + CoQ10 Mean (SD) Group I: 0.75 ± 0.4 Group II: 0.83 ± 0.4 Group III: 0.6 ± 0.4 The diagnosis was not biochemically validated This was a single-blind study, and the outcomes are likely to be influenced by the lack of blinding AEs were not reported as a specific outcome