Sanagoo 2013
(37)
(Iran, from March to July)
Unpublished
|
RCT
Single-blind
2 parallel-group
|
Patients of any age of both genders, with acute AlP poisoning (N= 66)
within the first 3 h of exposition
All people received standard treatment
-Group I: Coconut oil (N=33)
-Group II: Control group (N=33)
|
Mean
Group I: 2.6
Group II: 2.3
|
The diagnosis was not biochemically validated.
Random sequence generation and allocation concealment were not
detailed
AEs were not reported as a specific outcome
|
Dayananda 2018
(38)
(India, from March 2014 to August 2016)
|
RCT
¿?
2 parallel groups
|
Adults of both sexes, with acute AlP poisoning (N= 50). All
people received standard treatment
-Group I: Coconut oil
-Group II: Control group
|
Mean
Group I: 2.24
Group II:
2.48
|
Blinding, random sequence generation and allocation concealment were
not detailed
AEs were not reported as a specific outcome
|
Darwish
2020
(39)
(Egypt,
between June 2018 and May 2019)
|
RCT
Double-blind
3 parallel groups
|
Patients aged more than 18 years of both genders, with acute AlP
poisoning within the first 6 h of exposition (N= 90).
All people received standard treatment
-Group I: KMNO4 solution (1:10 000)
This group was a historical control (N=30)
-Group II: Paraffin oil (N=30)
-Group III: Co Q10 + Paraffin oil (N=30)
|
Mean (SD)
Group I: 0.97 ± 0.50
Group II:
0.83 ± 0.36
Group III:
1.15 ± 0.73
|
The diagnosis was not biochemically validated.
The allocation concealment method was not described.
AEs were not reported as a specific outcome.
|
Helal 2022
(40)
(Egypt 2020, from June to November)
|
RCT
Single-blind
2 parallel-group
(Phase 2)
|
Patients aged more than 18 years of both genders, with acute AlP
poisoning within the first 0.5 to 2.5 h of exposition
(N= 62). All people received standard treatment
-Group I (N=31): Paraffin oil
-Group II (N=31): Control group
|
Mean (SD)
Group I: 1.1 ± 0.18
Group II:
1.3 ± 0.43
|
This was a single-blind study, and the outcomes are likely to be
influenced by the lack of blinding
AEs were not reported as a specific outcome
|
Abdelhamid 2023
(41)
(Egypt, from January to December 2020)
|
RCT
Single-blind
3 parallel groups
|
Adults of both sexes, with acute AlP poisoning within the first
6 hs of exposition (N=96). All people received standard
treatment
-Group I (N=32): N-acetyl cysteine (NAC)
-Group II (N=32): NAC + L- carnitine
-Group III (N=32): NAC + Paraffin oil
|
Mean (SD)
Group I: 1.47 ± 0.8
Group II:
1.47 ± 0.6
Group III:
1.8 ± 0.6
|
The diagnosis was not biochemically validated
This was a single-blind study, and the outcomes are likely to be
influenced by the lack of blinding
AEs were not reported as a specific outcome
|
Elbastawesy 2023
(42)
(Egypt between January, and June 2021)
|
RCT
Double-blind
3 parallel groups
|
Patients aged more than 12 years of both genders, with acute AlP
poisoning within the first 2 h of exposition (N= 60).
All people received standard treatment
-Group I (N=20): Paraffin oil
-Group II (N=20): Coconut oil
-Group III (N=20): Control group
|
Mean (SD)
Group I: 1.0 ± 0
Group II: 0.83 ± 0.4
Group III:
0.83 ± 0.4
|
This was the trial rated with the lowest risk of bias
AEs were reported as a specific outcome
|
Elsharkawy 2023
(43)
(Egypt, between December to November 2021)
|
RCT
Single-blind
3 parallel groups
(Phase 2)
|
Patients aged more than 18 years of both genders, with acute AlP
poisoning within the first 6 h of exposition (N= 84). All
people received standard treatment
-Group I (N=28): Control group
-Group II (N=28): Coconut oil
-Group III (N=28): Coconut oil + CoQ10
|
Mean (SD)
Group I: 0.75 ± 0.4
Group II: 0.83 ± 0.4
Group III:
0.6 ± 0.4
|
The diagnosis was not biochemically validated
This was a single-blind study, and the outcomes are likely to be
influenced by the lack of blinding
AEs were not reported as a specific outcome
|