The search strategy was agreed upon by the
authors and replicable, obtaining all relevant studies. The review was
done in duplicate to establish the eligibility of the studies. Two
researchers were involved in screening (ODS, CDN) using the Covidence
tool
(https://www.covidence.org). We
use Medeley Cite
(https://mendeley.com) as software
to manage references. An exhaustive search of the scientific literature
was carried out in each of the following databases from the beginning of
the report until November 2023, identifying RCTs that evaluated the
efficacy of varenicline for the treatment of people with AUD regardless
of its publication status: PubMed (https://PubMed.ncbi.nlm.nih.gov),
Cochrane Library (https://www.cochranelibrary.com/), SciELO
(https://SciELO.org/es/), Science Direct
(https://www.ScienceDirect.com/), Google Scholar
(https://scholar.google.com/) Europe PMC (https://europepmc.org/), Trip
Database (https://www.tripdatabase.com/), LILACS
(https://LILACS.bvsalud.org/es/) and Index Medicus for South-East Asia
Region, IMSEAR
(https://imsear.searo.who.int/handle/123456789/205654)