Mortality. Four RCT (39) (40) (41) (42)
comparing GL with paraffin oil to standard therapy, covering 226
participants with acute AlP poisoning, 113 of whom received paraffin
oil, delivering a RR of 0.62, 95% CI 0.48 to 0.81 (Figure 4 :
Forest plot of comparison: Paraffin oil versus standard therapy,
outcome: 1.1 Mortality) with a level of heterogeneity not relevant
(I2 = 10%). Likewise, the analysis remained robust in
other summary statistics, delivering an OR of 0.31 (95% CI 0.18 to
0.54; I²= 0%). Following the sensitivity analysis, by removing from the
analysis the trials classified as having a high risk of bias (40) (41) a
major decrease in the estimate of the effect is found (RR 0.66; 95% CI:
0.40 to 1.08) also with an increase of the I² value to 58%
(Figure 5 : Forest plot of comparison: Sensitivity Analysis
outcome 1.1). Only two trials reported biochemical validation of the
diagnosis of acute poisoning (40) (42), by the silver nitrate test,
which could detect phosphine gas in stomach aspirate
(44).