Results:
One hundred and thirty patients were enrolled in the study, eight patients were excluded due to deviation from the protocol. Two of the patients in group bolus had paracetamol allergy. In one patient from the same group, the laryngeal mask could not be placed despite two attempts because the mouth opening was not sufficient, and face mask ventilation was performed. One patient in this group had excessive rigidity. It was necessary to administer muscle relaxant and the patient was excluded from the study. Three of the patients in group BIS required a bolus of propofol after the infusion was stopped, because the bleeding control was longer than expected. One patient had a BIS value of 80 after placement of a laryngeal mask, and bolus propofol was required to provide adequate anesthesia despite increasing the infusion dose. As a result, one hundred and twenty-two patients completed the study: group bolus; n=61 and, group BIS; n=61 (Figure 1).
The age, weight, height, BMI, and the distribution of ASA score were similar in both groups (Table 1).
There was no difference between the groups regarding of number of attempts for the insertion of the laryngeal mask (Table 1).
No hemodynamic difference was observed between the groups, except the occurrence of bradycardia during the procedure. More patients in group BIS had bradycardia than patients in group bolus, therefore, the number of patients treated with atropine was different between the groups (group BIS; 27 patient vs group bolus; 11 patient, p=0.003) (Table 1). Rigidity was observed in one patient in each group (p=1) (Table 1).
There was no difference between groups in terms of duration of anesthesia (22.37±6.79 min vs 23.04±8.09 min) and duration of procedure (16.63±6.62 min vs 16.19±7.61 min) (respectively, p= 0.620, p=0.733) (Table 2).
There was no difference in the time to reach the value of 5 on the MOASs between the groups (Table 2).
The amount of total propofol was significantly higher in the group BIS (278.95±95.04mg) than in the group bolus (231.06±62.40mg) (p=0.001) (Table 2).
The time for the patient to reach the value of PADSS≥9 in the postoperative period was statistically longer in the group BIS (83.69±32.40 min) than in the group bolus (71.72±25.41 min) (p=0.026) (Table 2).
In the postoperative period, none of the patients needed rescue analgesics. One patient in the group bolus required ondansetron. No patient in the group BIS required antiemetic treatment.
Satisfaction of the patients and the gynecologist did not differ significantly between the groups (Table 1).