Abstract:
Objective: To investigate whether the use of bispectral index
(BIS) monitoring would decrease total propofol consumption during the
transvaginal oocyte retrieval procedure
Design: Prospective, randomized, controlled, parallel-group
clinical trial
Setting: Operating room, postoperative recovery room
Population: One hundred and thirty, American Society of
Anesthesiologists (ASA) I-II patients, over age 18, undergoing
transvaginal oocyte retrieval
Methods: All patients were administered 2µg/kg fentanyl, and
2mg/kg propofol for the induction of anesthesia. The patients were
divided into two groups. Patients in the group bolus were given 0.5
mg/kg of propofol when necessary, according to the observer’s range of
motion. Patients in the group BIS were given 10 mg/kg/hour propofol
infusion adjusted to keep the BIS value between 40-60.
Main Outcome Measures: The primary outcome was the total dose
of propofol administered per patient. The secondary outcomes were the
time to reach the value of 5 on the Modified Observer’s Assessment of
Alertness Sedation Scale (MOASs), the time to reach Post Anesthetic
Discharge Scoring System (PADSS) ≥9 of the patients, satisfaction of the
patient, and the gynecologist.
Results: The amount of total propofol was higher in the group
BIS than in the group bolus administered according to the patient’s
clinic. There was no difference in the time to reach the value of 5 on
the MOASs between the groups. The time to reach PADSS ≥9 was longer in
the group BIS than in the group bolus. There was no difference between
the two groups in terms of the satisfaction of the patient and the
gynecologist.
Conclusion: Administration of propofol as an infusion with BIS
monitoring did not reduce the amount of propofol administered to
patients during transvaginal oocyte retrieval.
Funding: This research did not receive any specific grants from
funding agencies in the public, commercial, or not-for-profit sectors.
Keywords: BIS, propofol, oocyte retrieval
Clinical trial registration number: NCT05631925 - 12/03/2022