Conclusions
In this study, APMCG-1 was first isolated from ethanol-extracted MCG residue. The functional promotion of APMCG-1 in cardiomyocytes and skeletal myoblasts was systemically explored. Through the PI3K/AKT signaling pathway, APMCG-1 decreases palmitic acid-induced apoptosis in H9c2 and C2C12 cells. In type 2 diabetic zebrafish, APMCG-1 can reduce the levels of cardiac and muscle apoptosis, oxidative stress, inflammation, and glucose lipid metabolism problem. Further, chemical and structural analyses confirmed the presence of polysaccharides and peptides in APMCG-1, and we demonstrated that APMCG-1 is a glycopeptide. Therefore, the present findings proved that APMCG-1 may have attractive significance for the prevention and treatment of muscle-related diseases.