Conclusions
In this study, APMCG-1 was first isolated from ethanol-extracted MCG
residue. The functional promotion of APMCG-1 in cardiomyocytes and
skeletal myoblasts was systemically explored. Through the PI3K/AKT
signaling pathway, APMCG-1 decreases palmitic acid-induced apoptosis in
H9c2 and C2C12 cells. In type 2 diabetic zebrafish, APMCG-1 can reduce
the levels of cardiac and muscle apoptosis, oxidative stress,
inflammation, and glucose lipid metabolism problem. Further, chemical
and structural analyses confirmed the presence of polysaccharides and
peptides in APMCG-1, and we demonstrated that APMCG-1 is a glycopeptide.
Therefore, the present findings proved that APMCG-1 may have attractive
significance for the prevention and treatment of muscle-related
diseases.