Search Strategy
We developed a search strategy using Medical Subject Headings (MeSH)
related to chemotherapy-induced ototoxicity. We searched three databases
(Medline, CINHAL, and PubMed) using the following search string:(Ototoxicity OR Drug-Induced Ototoxicity OR Drug-Related
Otological Toxicities OR Drug-Induced Cochleotoxicity OR Drug Induced
Cochlear Toxicity OR Drug Induced Vestibulotoxicity OR vertigo OR
tinnitus) AND (Antineoplastic Agent OR Anticancer Agent OR
Antineoplastic Drug OR Antineoplastic OR Antitumor Drug OR Cancer
Chemotherapy Agent OR Antitumor Agent OR Cancer Chemotherapy Drug OR
Chemotherapeutic Anticancer Agents OR Chemotherapeutic Anticancer Drug
OR Combined Antineoplastic Agents OR Antineoplastic Combined
Chemotherapy Regimens) . The systematic review protocol was registered
with the International Prospective Register of Systematic Reviews
(CRD42022376324). The search results were downloaded into Endnote
software to remove duplicates. The debugged search was uploaded to
Rayyan where two reviewers (JEC and NM) screened abstracts and selected
relevant titles with a 0.43 inter-rater agreement. In the event of a
conflict of views, a consensus was reached through discussion. Further
to ensure consistency in eligibility criteria the full texts were
reviewed by the seven authors. There was a vote in case of disagreement.
References from selected articles were also included. We report the
results following the Preferred Reporting Items for Systematic Reviews
and Meta-Analysis (PRISMA)(Page et al. 2021)(Figure 1.).