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\begin{document}

\title{Frequency and burden of disease for SARS-CoV-2 and other viral
respiratory tract infections in children under the age of 2 months}



\author[1]{Marie Latouche}%
\author[2]{Mahdi Ouafi}%
\author[1]{Ilka Engelmann}%
\author[2]{Adrien Becquart}%
\author[1]{Enagnon Kazali Alidjinou}%
\author[2]{Ayoub Mitha}%
\author[2]{francois dubos}%
\affil[1]{University of Lille}%
\affil[2]{CHU Lille}%


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  \date{June 13, 2024}


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\begin{abstract}
Background: To evaluate the frequency and burden of disease of
SARS-CoV-2 and other respiratory viruses in children under the age of 2
months. Methods: A retrospective, cross-sectional, single-center study
was conducted between March 2021, and February 2022. All children under
the age of 2 months and tested for SARS-CoV-2 were included. The
frequency of SARS-CoV-2, of other respiratory viruses and the burden of
disease caused by SARS-CoV-2 and other respiratory viruses were
evaluated. Results: 727 children with an RT-PCR test for SARS-CoV-2 were
included (mean age: 0.9 months (\selectlanguage{ngerman}±0.6); boys: 57\%); 514 (71\%) in the
emergency room and 213 (29\%) in hospital. Among them, 62 (8.5\%) had a
positive RT-PCR test for SARS-CoV-2, more often in the Omicron period
(23\%) than in the Alpha period (4\%). Of the 565 (78\%) with a
multiplex RT-PCR test for other viruses, 325 (58\%) were positive.
Children with a positive SARS-CoV-2 were less likely to have required
respiratory support (p=.001), enteral nutrition (p=.03), or intensive
care admission (p=.01) and had a shorter hospital stay than children
with other respiratory viruses (5d vs. 7d, p=.007). Conclusion: In this
young population of children, SARS-CoV-2 infection was less frequent and
less severe than other viral respiratory infections.%
\end{abstract}\selectlanguage{ngerman}%



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\textbf{Hosted file}

\verb`Main document_Covid M2M_IORV.docx`  available at \url{https://authorea.com/users/601833/articles/632860-frequency-and-burden-of-disease-for-sars-cov-2-and-other-viral-respiratory-tract-infections-in-children-under-the-age-of-2-months}\selectlanguage{english}
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