Author Contributions:
Jingchao Sun: study design, statistical analysis and manuscript drafting
Jie Yan and Ying Xiao: Provide compounds and participate in study design
Wei Xing and Yinsuo Lu: participate in statistical analysis
Frank Du, Maozhi Tian, Danqi Xu, Yihua Ren and Xin Fang: participate in study design, run the study, analysis and data collection
Wenjie Xu: review the study design and manuscript